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When no assumptions were made about age-dependent penetrance, significant results were still obtained (Z\n            <jats:sub>max<\/jats:sub>\n            = 5.94, \u03b8 = 0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.\n          <\/jats:p>","DOI":"10.1126\/science.1411576","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:03:06Z","timestamp":1160089386000},"page":"668-671","source":"Crossref","is-referenced-by-count":705,"title":["Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14"],"prefix":"10.1126","volume":"258","author":[{"given":"Gerard D.","family":"Schellenberg","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Washington, Seattle, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Bird","sequence":"additional","affiliation":[{"name":"Division of Neurology, Veterans Affairs Medical Center, Seattle, WA 98108."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Wijsman","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry T.","family":"Orr","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology and the Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leojean","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Washington, Seattle, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Nemens","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Washington, Seattle, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June A.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Bonnycastle","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, University of Washington, Seattle, WA 98195."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Weber","sequence":"additional","affiliation":[{"name":"Marshfield Medical Research Foundation, Marshfield, WI 54449."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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