{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:53:56Z","timestamp":1774882436170,"version":"3.50.1"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5010","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1991,5,31]]},"abstract":"<jats:p>\n            A complementary DNA encoding a G protein-coupled glutamate receptor from rat brain, Glu\n            <jats:sub>G<\/jats:sub>\n            R, was cloned by functional expression in\n            <jats:italic>Xenopus<\/jats:italic>\n            oocytes. The complementary DNA encodes a protein of 1199 amino acids containing a seven-transmembrane motif, flanked by large amino- and carboxyl-terminal domains. This receptor lacks any amino acid sequence similarity with other G protein-coupled receptors, suggesting that it may be a member of a new subfamily. The presence of two introns flanking the central core suggests that Glu\n            <jats:sub>G<\/jats:sub>\n            R may have evolved by exon shuffling. Expressed in oocytes, Glu\n            <jats:sub>G<\/jats:sub>\n            R is activated by quisqualate &gt; glutamate &gt; ibotenate &gt;\n            <jats:italic>trans<\/jats:italic>\n            -1-aminocyclopentyl-1,3-dicarboxylate, and it is inhibited by 2-amino-3-phosphonopropionate. Activation is blocked by\n            <jats:italic>Bordella pertussis<\/jats:italic>\n            toxin. These properties are typical of some metabotropic glutamate receptors.\n          <\/jats:p>","DOI":"10.1126\/science.1656524","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:10:16Z","timestamp":1160071816000},"page":"1318-1321","source":"Crossref","is-referenced-by-count":392,"title":["Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain"],"prefix":"10.1126","volume":"252","author":[{"given":"Khaled M.","family":"Houamed","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L.","family":"Kuijper","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology and DNA Chemistry, ZymoGenetics, Seattle, WA 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa L.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology and DNA Chemistry, ZymoGenetics, Seattle, WA 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty A.","family":"Haldeman","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology and DNA Chemistry, ZymoGenetics, Seattle, WA 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"O'Hara","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology and DNA Chemistry, ZymoGenetics, Seattle, WA 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen R.","family":"Mulvihill","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology and DNA Chemistry, ZymoGenetics, Seattle, WA 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfhard","family":"Almers","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick S.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology and DNA Chemistry, ZymoGenetics, Seattle, WA 98105."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"4316","volume":"86","year":"1989","unstructured":"BLACKSTONE, C.D., INOSITOLPHOSPHOLIPID-LINKED GLUTAMATE RECEPTORS MEDIATE CEREBELLAR PARALLEL-FIBER PURKINJE-CELL SYNAPTIC TRANSMISSION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 4316 (1989).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2168579"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/347765a0","volume":"347","year":"1990","unstructured":"CHARPAK, S, POTASSIUM CONDUCTANCES IN HIPPOCAMPAL-NEURONS BLOCKED BY EXCITATORY AMINO-ACID TRANSMITTERS, NATURE 347: 765 (1990).","journal-title":"NATURE"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00591a005"},{"key":"e_1_2_1_5_1","first-page":"143","volume":"41","year":"1989","unstructured":"COLLINGRIDGE, G.L., EXCITATORY AMINO-ACID RECEPTORS IN THE VERTEBRATE CENTRAL NERVOUS-SYSTEM, PHARMACOLOGICAL REVIEWS 41: 143 (1989).","journal-title":"PHARMACOLOGICAL REVIEWS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0169-328X(86)90026-4","volume":"1","year":"1986","unstructured":"DASCAL, N, INVOLVEMENT OF A GTP-BINDING PROTEIN IN MEDIATION OF SEROTONIN AND ACETYLCHOLINE RESPONSES IN XENOPUS OOCYTES INJECTED WITH RAT-BRAIN MESSENGER-RNA, MOLECULAR BRAIN RESEARCH 1: 201 (1986).","journal-title":"MOLECULAR BRAIN RESEARCH"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2418503"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/syn.890020613","volume":"2","year":"1988","unstructured":"FONG, T.M., PROPERTIES OF 2 CLASSES OF RAT-BRAIN ACIDIC AMINO-ACID RECEPTORS INDUCED BY DISTINCT MESSENGER-RNA POPULATIONS IN XENOPUS OOCYTES, SYNAPSE 2: 657 (1988).","journal-title":"SYNAPSE"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1113\/jphysiol.1989.sp017702","volume":"414","year":"1989","unstructured":"FURUYA, S, INTRACELLULAR CALCIUM MOBILIZATION TRIGGERED BY A GLUTAMATE RECEPTOR IN RAT CULTURED HIPPOCAMPAL CELLS, JOURNAL OF PHYSIOLOGY-LONDON 414: 539 (1989).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(83)90230-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/342643a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2166337"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90515-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0896-6273(90)90200-Y","volume":"4","year":"1990","unstructured":"LESTER, RAJ, QUISQUALATE RECEPTOR-MEDIATED DEPRESSION OF CALCIUM CURRENTS IN HIPPOCAMPAL-NEURONS, NEURON 4: 741 (1990).","journal-title":"NEURON"},{"key":"e_1_2_1_15_1","first-page":"1","volume":"38","year":"1990","unstructured":"MANZONI, O, (TRANS)-1-AMINO-CYCLOPENTYL-1,3-DICARBOXYLATE STIMULATES QUISQUALATE PHOSPHOINOSITIDE-COUPLED RECEPTORS BUT NOT IONOTROPIC GLUTAMATE RECEPTORS IN STRIATAL NEURONS AND XENOPUS OOCYTES, MOLECULAR PHARMACOLOGY 38: 1 (1990).","journal-title":"MOLECULAR PHARMACOLOGY"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/349760a0","volume":"349","year":"1991","unstructured":"MASU, M, SEQUENCE AND EXPRESSION OF A METABOTROPIC GLUTAMATE RECEPTOR, NATURE 349: 760 (1991).","journal-title":"NATURE"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(87)90011-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0165-6147(90)90254-6","volume":"11","year":"1990","unstructured":"MAYER, M.L., EXCITATORY AMINO-ACID RECEPTORS, 2ND MESSENGERS AND REGULATION OF INTRACELLULAR CA-2+ IN MAMMALIAN NEURONS, TRENDS IN PHARMACOLOGICAL SCIENCES 11: 254 (1990).","journal-title":"TRENDS IN PHARMACOLOGICAL SCIENCES"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2502842"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.18.7035"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF00582635","volume":"407","year":"1986","unstructured":"METHFESSEL, C, PATCH CLAMP MEASUREMENTS ON XENOPUS-LAEVIS OOCYTES - CURRENTS THROUGH ENDOGENOUS CHANNELS AND IMPLANTED ACETYLCHOLINE-RECEPTOR AND SODIUM-CHANNELS, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 407: 577 (1986).","journal-title":"PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.29.040189.002053"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"13524","DOI":"10.1016\/S0021-9258(18)80028-X","volume":"264","year":"1989","unstructured":"MORIARTY, T.M., COUPLING OF EXOGENOUS RECEPTORS TO PHOSPHOLIPASE-C IN XENOPUS OOCYTES THROUGH PERTUSSIS TOXIN-SENSITIVE AND TOXIN-INSENSITIVE PATHWAYS - CROSS-TALK THROUGH HETEROTRIMERIC G-PROTEINS, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 13524 (1989).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/nar\/10.2.459","volume":"10","year":"1982","unstructured":"MOUNT, S.M., A CATALOG OF SPLICE JUNCTION SEQUENCES, NUCLEIC ACIDS RESEARCH 10: 459 (1982).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_25_1","unstructured":"MULVIHILL E unpublished data."},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1471-4159.1986.tb12922.x","volume":"46","year":"1986","unstructured":"NICOLETTI, F, COUPLING OF INOSITOL PHOSPHOLIPID-METABOLISM WITH EXCITATORY AMINO-ACID RECOGNITION SITES IN RAT HIPPOCAMPUS, JOURNAL OF NEUROCHEMISTRY 46: 40 (1986).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0028-3908(88)90174-8","volume":"27","year":"1988","unstructured":"NICOLETTI, F, PERTUSSIS TOXIN INHIBITS SIGNAL TRANSDUCTION AT A SPECIFIC METABOLOTROPIC GLUTAMATE RECEPTOR IN PRIMARY CULTURES OF CEREBELLAR GRANULE CELLS, NEUROPHARMACOLOGY 27: 551 (1988).","journal-title":"NEUROPHARMACOLOGY"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.ne.12.030189.000435","volume":"12","year":"1989","unstructured":"ODOWD, B.F., STRUCTURE OF THE ADRENERGIC AND RELATED RECEPTORS, ANNUAL REVIEW OF NEUROSCIENCE 12: 67 (1989).","journal-title":"ANNUAL REVIEW OF NEUROSCIENCE"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/jphysiol.1989.sp017456","volume":"408","year":"1989","unstructured":"OOSAWA, Y, RAT-BRAIN GLUTAMATE RECEPTORS ACTIVATE CHLORIDE CHANNELS IN XENOPUS OOCYTES COUPLED BY INOSITOL TRISPHOSPHATE AND CA-2+, JOURNAL OF PHYSIOLOGY-LONDON 408: 223 (1989).","journal-title":"JOURNAL OF PHYSIOLOGY-LONDON"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-2999(89)90383-X","volume":"166","year":"1989","unstructured":"PALMER, E, TRANS-ACPD, A SELECTIVE AGONIST OF THE PHOSPHOINOSITIDE-COUPLED EXCITATORY AMINO-ACID RECEPTOR, EUROPEAN JOURNAL OF PHARMACOLOGY 166: 585 (1989).","journal-title":"EUROPEAN JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2556796"},{"key":"e_1_2_1_32_1","first-page":"2444","volume":"85","year":"1988","unstructured":"PEARSON, W.R., IMPROVED TOOLS FOR BIOLOGICAL SEQUENCE COMPARISON, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 2444 (1988).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5463"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0165-6147(90)90052-A","volume":"11","year":"1990","unstructured":"SCHOEPP, D, PHARMACOLOGICAL AND FUNCTIONAL-CHARACTERISTICS OF METABOTROPIC EXCITATORY AMINO-ACID RECEPTORS, TRENDS IN PHARMACOLOGICAL SCIENCES 11: 508 (1990).","journal-title":"TRENDS IN PHARMACOLOGICAL SCIENCES"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1471-4159.1989.tb07324.x","volume":"53","year":"1989","unstructured":"SCHOEPP, D.D., COMPARISON OF EXCITATORY AMINO ACID-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS AND N-[H-3]ACETYLASPARTYLGLUTAMATE BINDING IN RAT-BRAIN - SELECTIVE-INHIBITION OF PHOSPHOINOSITIDE HYDROLYSIS BY 2-AMINO-3-PHOSPHONOPROPIONATE, JOURNAL OF NEUROCHEMISTRY 53: 273 (1989).","journal-title":"JOURNAL OF NEUROCHEMISTRY"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/317717a0","volume":"317","year":"1985","unstructured":"SLADECZEK, F, GLUTAMATE STIMULATES INOSITOL PHOSPHATE FORMATION IN STRIATAL NEURONS, NATURE 317: 717 (1985).","journal-title":"NATURE"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1699275"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0014-2999(89)90529-3","volume":"173","year":"1989","unstructured":"STRATTON, K.R., EXCITATION OF HIPPOCAMPAL-NEURONS BY STIMULATION OF GLUTAMATE QP RECEPTORS, EUROPEAN JOURNAL OF PHARMACOLOGY 173: 235 (1989).","journal-title":"EUROPEAN JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0014-2999(90)90461-E","volume":"186","year":"1990","unstructured":"STRATTON, K.R., PHARMACOLOGICAL CHARACTERIZATION OF PHOSPHOINOSITIDE-LINKED GLUTAMATE RECEPTOR EXCITATION OF HIPPOCAMPAL-NEURONS, EUROPEAN JOURNAL OF PHARMACOLOGY 186: 357 (1990).","journal-title":"EUROPEAN JOURNAL OF PHARMACOLOGY"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/325531a0","volume":"325","year":"1987","unstructured":"SUGIYAMA, H, A NEW TYPE OF GLUTAMATE RECEPTOR LINKED TO INOSITOL PHOSPHOLIPID-METABOLISM, NATURE 325: 531 (1987).","journal-title":"NATURE"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0896-6273(89)90121-9","volume":"3","year":"1989","unstructured":"SUGIYAMA, H, GLUTAMATE RECEPTOR SUBTYPES MAY BE CLASSIFIED INTO 2 MAJOR CATEGORIES - A STUDY ON XENOPUS OOCYTES INJECTED WITH RAT-BRAIN MESSENGER-RNA, NEURON 3: 129 (1989).","journal-title":"NEURON"},{"key":"e_1_2_1_42_1","first-page":"5063","volume":"84","year":"1987","unstructured":"TAKAHASHI, T, RAT-BRAIN SEROTONIN RECEPTORS IN XENOPUS OOCYTES ARE COUPLED BY INTRACELLULAR CALCIUM TO ENDOGENOUS CHANNELS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 5063 (1987).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"6545","DOI":"10.1016\/S0021-9258(18)83382-8","volume":"264","year":"1989","unstructured":"Thorpe, D. S., Journal of Biological Chemistry 264: 6545 (1989).","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/14.11.4683"},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0014-2999(90)90194-B","volume":"179","year":"1990","unstructured":"WATSON, G.B., SELECTIVE ACTIVATION OF OSCILLATORY CURRENTS BY TRANS-ACPD IN RAT-BRAIN MESSENGER RNA-INJECTED XENOPUS OOCYTES AND THEIR BLOCKADE BY NMDA, EUROPEAN JOURNAL OF PHARMACOLOGY 179: 479 (1990).","journal-title":"EUROPEAN JOURNAL OF PHARMACOLOGY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1656524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T09:00:55Z","timestamp":1704963655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1656524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5,31]]},"references-count":45,"journal-issue":{"issue":"5010","published-print":{"date-parts":[[1991,5,31]]}},"alternative-id":["10.1126\/science.1656524"],"URL":"https:\/\/doi.org\/10.1126\/science.1656524","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,5,31]]}}}