{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:16:14Z","timestamp":1775265374070,"version":"3.50.1"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5032","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>\n            Enteropathogenic\n            <jats:italic>Escherichia coli<\/jats:italic>\n            (EPEC), a cause of childhood diarrhea, grow on the surface of the small intestine and on cultured epithelial cells as colonies of adherent bacteria. When propagated on solid medium containing blood or attached to HEp-2 cells, EPEC express ropelike bundles of filaments, termed bundle-forming pili (BFP), that create a network of fibers that bind together the individual organisms. BFP were found to be expressed by five EPEC serogroups, each harboring a \u223c92-kilobase plasmid previously known to be important for virulence in humans. When two of these strains were cured of this plasmid, they neither expressed BFP nor grew as adherent colonies. An antiserum to BFP reduced the capacity of EPEC to infect cultured epithelial cells. BFP are composed of a repeating subunit of 19,500 daltons, the amino-terminal amino acid sequence of this subunit is homologous to that of the toxin-coregulated pilin of\n            <jats:italic>Vibrio cholerae<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1126\/science.1683004","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:16Z","timestamp":1160086216000},"page":"710-713","source":"Crossref","is-referenced-by-count":489,"title":["An Inducible Bundle-Forming Pilus of Enteropathogenic\n            <i>Escherichia coli<\/i>"],"prefix":"10.1126","volume":"254","author":[{"given":"Jorge A.","family":"Gir\u00f3n","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Suk Yue","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary K.","family":"Schoolnik","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Beckman Center, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1099\/00222615-28-1-49","volume":"28","year":"1989","unstructured":"ANDRADE, JRC, AN ENDOCYTIC PROCESS IN HEP-2 CELLS INDUCED BY ENTEROPATHOGENIC ESCHERICHIA-COLI, JOURNAL OF MEDICAL MICROBIOLOGY 28: 49 (1989).","journal-title":"JOURNAL OF MEDICAL MICROBIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/00005176-198302030-00023","volume":"2","year":"1983","unstructured":"BALDINI, M.M., PLASMID-MEDIATED ADHESION IN ENTEROPATHOGENIC ESCHERICHIA-COLI, JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION 2: 534 (1983).","journal-title":"JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/183782a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0022-3476(82)80429-0","volume":"100","year":"1982","unstructured":"CLAUSEN, C.R., CHRONIC DIARRHEA IN INFANTS CAUSED BY ADHERENT ENTEROPATHOGENIC ESCHERICHIA-COLI, JOURNAL OF PEDIATRICS 100: 358 (1982).","journal-title":"JOURNAL OF PEDIATRICS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02602439","volume":"3","year":"1979","unstructured":"CRAVIOTO, A, ADHESIVE FACTOR FOUND IN STRAINS OF ESCHERICHIA-COLI BELONGING TO THE TRADITIONAL INFANTILE ENTEROPATHOGENIC SEROTYPES, CURRENT MICROBIOLOGY 3: 95 (1979).","journal-title":"CURRENT MICROBIOLOGY"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/mr.52.2.233-247.1988","volume":"52","year":"1988","unstructured":"ELLEMAN, T.C., PILINS OF BACTEROIDES-NODOSUS - 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