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The repertoire of T cells is shaped through contact with MHC molecules in the thymus and involves a complex process of positive selection and negative selection (tolerance). Tolerance of immature T cells to MHC molecules can reflect either clonal deletion or anergy and results from intrathymic contact with several cell types, including epithelial cells and cells with antigen-presenting function. Unlike immature T cells, mature T cells are relatively resistant to tolerance induction. In certain situations partial unresponsiveness of mature T cells can be achieved by exposing T cells to foreign MHC molecules expressed on atypical antigen-presenting cells. Tolerance is rarely complete, however, and the precise requirements for tolerizing mature T cells are still unclear.\n          <\/jats:p>","DOI":"10.1126\/science.1694041","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T22:10:14Z","timestamp":1160086214000},"page":"1357-1363","source":"Crossref","is-referenced-by-count":118,"title":["T Cell Reactivity to MHC Molecules: Immunity Versus Tolerance"],"prefix":"10.1126","volume":"248","author":[{"given":"Jonathan","family":"Sprent","sequence":"first","affiliation":[{"name":"Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037."}]},{"given":"Er-Kai","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037."}]},{"given":"Susan R.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.iy.07.040189.003343","volume":"7","year":"1989","unstructured":"ABE, R, T-CELL RECOGNITION OF MINOR LYMPHOCYTE STIMULATING (MLS) GENE-PRODUCTS, ANNUAL REVIEW OF IMMUNOLOGY 7: 683 (1989).","journal-title":"ANNUAL REVIEW OF IMMUNOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0092-8674(89)90501-1","volume":"58","year":"1989","unstructured":"BENOIST, C, POSITIVE SELECTION OF THE T-CELL REPERTOIRE - 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