{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:31:51Z","timestamp":1762075911312},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"3974","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1971,3,5]]},"abstract":"<jats:p>Embryonic tissue cells dissociated with ethylenediaminetetraacetate are readily agglutinated by the carbohydrate-binding protein concanavalin A. In this property, they resemble transformed, neoplastic cells; and they differ from untransformed adult cells, which are agglutinated by concanavalin A only after their receptors are unmasked by proteolytic treatment. Receptor sites for wheat germ agglutinin are also present on the surface of embryonic cells, but in a masked form, as on untransformed adult culture cells; they can be unmasked by treatment of the cells with trypsin. Concanavalin A binding sites on embryonic cells may function in cell contact and cell organization during embryonic morphogenesis and differentiation and later become masked in adult cells. The unmasking of these sites in neoplastic cells may represent a return, in this respect, to a condition resembling that of embryonic cells and may be related to cell mobility associated with infiltration and metastasis.<\/jats:p>","DOI":"10.1126\/science.171.3974.905","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:17:43Z","timestamp":1160054263000},"page":"905-907","source":"Crossref","is-referenced-by-count":162,"title":["Embryonic and Neoplastic Cell Surfaces: Availability of Receptors for Concanavalin A and Wheat Germ Agglutinin"],"prefix":"10.1126","volume":"171","author":[{"given":"A. A.","family":"Moscona","sequence":"first","affiliation":[{"name":"Department of Biology, University of Chicago, Chicago, Illinois 60637"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"359","volume":"57","year":"1967","unstructured":"BURGER, M.M., IDENTIFICATION OF A TUMOR-SPECIFIC DETERMINANT ON NEOPLASTIC CELL SURFACES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 57: 359 (1967).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/223710a0","volume":"223","year":"1969","unstructured":"INBAR, M, STRUCTURAL DIFFERENCE IN SITES ON SURFACE MEMBRANE OF NORMAL AND TRANSFORMED CELLS, NATURE 223: 710 (1969).","journal-title":"NATURE"},{"key":"e_1_2_1_3_1","first-page":"1418","volume":"63","year":"1969","unstructured":"INBAR, M, INTERACTION OF CARBOHYDRATE-BINDING PROTEIN CONCANAVALIN A WITH NORMAL AND TRANSFORMED CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 63: 1418 (1969).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_4_1","unstructured":"Kleinschuster S. in preparation."},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0070-2153(08)60484-6","volume":"4","year":"1969","unstructured":"LILIEN, J.E., CURR TOP DEV BIOL 4: 169 (1969).","journal-title":"CURR TOP DEV BIOL"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.157.3784.70"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0012-1606(68)90035-3","volume":"18","year":"1968","unstructured":"MOSCONA, A.A., CELL AGGREGATION - PROPERTIES OF SPECIFIC CELL-LIGANDS AND THEIR ROLE IN FORMATION OF MULTICELLULAR SYSTEMS, DEVELOPMENTAL BIOLOGY 18: 250 (1968).","journal-title":"DEVELOPMENTAL BIOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/0014-4827(61)90122-7","volume":"22","year":"1961","unstructured":"MOSCONA, A.A., ROTATION-MEDIATED HISTOGENETIC AGGREGATION OF DISSOCIATED CELLS - A QUANTIFIABLE APPROACH TO CELL INTERACTIONS IN VITRO, EXPERIMENTAL CELL RESEARCH 22: 455 (1961).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0014-4827(66)80126-X","volume":"41","year":"1966","unstructured":"MOSCONA, A.A., AGGREGATION OF EMBRYONIC CELLS IN A SERUM-FREE MEDIUM AND ITS INHIBITION AT SUBOPTIMAL TEMPERATURES, EXPERIMENTAL CELL RESEARCH 41: 697 (1966).","journal-title":"EXPERIMENTAL CELL RESEARCH"},{"key":"e_1_2_1_10_1","first-page":"13","volume":"3","year":"1968","unstructured":"Moscona, A. 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