{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:13:55Z","timestamp":1776960835108,"version":"3.51.4"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5328","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1997,8,15]]},"abstract":"<jats:p>\n            A\n            <jats:italic>C. elegans<\/jats:italic>\n            neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage.\n            <jats:italic>daf-2<\/jats:italic>\n            , a key gene in the genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases in DAF-2 signaling induce metabolic and developmental changes, as in mammalian metabolic control by the insulin receptor. Decreased DAF-2 signaling also causes an increase in life-span. Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity.\n          <\/jats:p>","DOI":"10.1126\/science.277.5328.942","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:37:56Z","timestamp":1027748276000},"page":"942-946","source":"Crossref","is-referenced-by-count":1886,"title":["<i>daf-2<\/i>\n            , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in\n            <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1126","volume":"277","author":[{"given":"Koutarou D.","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA."}]},{"given":"Heidi A.","family":"Tissenbaum","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA."}]},{"given":"Yanxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA."}]},{"given":"Gary","family":"Ruvkun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA."}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","unstructured":"D. L. Riddle in Caenorhabditis elegans II D. Riddle T. Blumenthal B. Meyer J. Priess Ed. (Cold Spring Harbor Laboratory Press Cold Spring Harbor NY 1997) pp. 739\u2013768; C. Kenyon ibid. pp. 791\u2013813."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/genetics\/130.1.105","volume":"130","author":"Vowels J. J.","year":"1992","unstructured":"Vowels J. J., Thomas J. H., Genetics 130, 105 (1992);","journal-title":"Genetics"},{"key":"e_1_3_1_3_3","first-page":"107","volume":"137","author":"Gottlieb S.","year":"1994","unstructured":"Gottlieb S., Ruvkun G., ibid. 137, 107 (1994);","journal-title":"ibid."},{"key":"e_1_3_1_3_4","doi-asserted-by":"crossref","unstructured":"; J. H. Thomas D. A. Birnby J. J. Vowels ibid. 134 1105 (1993).","DOI":"10.1093\/genetics\/134.4.1105"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","unstructured":"P. L. Larsen P. S. Albert D. L. 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A.","year":"1994","unstructured":"Malone E. A., Thomas J. H., Genetics 136, 879 (1994).","journal-title":"Genetics"},{"key":"e_1_3_1_29_2","unstructured":"We thank A. Coulson S. Chissoe B. Waterston T. Barnes E. Zachgo E. Malone T. Inoue J. Thomas E. Lambie J. Avruch J. Kaplan the Massachusetts General Hospital sequencing facility the C. elegans Genetics Center and the Ruvkun and Kaplan labs for assistance. K.D.K. is supported by the Japanese Society for the Promotion of Science. This work was supported by NIH grant RO1AG14161."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.277.5328.942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T00:45:34Z","timestamp":1705106734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.277.5328.942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,15]]},"references-count":47,"journal-issue":{"issue":"5328","published-print":{"date-parts":[[1997,8,15]]}},"alternative-id":["10.1126\/science.277.5328.942"],"URL":"https:\/\/doi.org\/10.1126\/science.277.5328.942","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8,15]]}}}