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Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors. Similarly, it may be possible to identify and validate new targets for drugs that would selectively kill tumor cells with a particular molecular context. This article outlines some of the ways that yeast genetics can be used to streamline anticancer drug discovery.<\/jats:p>","DOI":"10.1126\/science.278.5340.1064","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:44:47Z","timestamp":1027763087000},"page":"1064-1068","source":"Crossref","is-referenced-by-count":696,"title":["Integrating Genetic Approaches into the Discovery of Anticancer Drugs"],"prefix":"10.1126","volume":"278","author":[{"given":"Leland H.","family":"Hartwell","sequence":"first","affiliation":[{"name":"L. H. 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