{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:33:36Z","timestamp":1776306816751,"version":"3.50.1"},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5361","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1998,4,10]]},"abstract":"<jats:p>A general method is introduced for the rapid and simultaneous evaluation of each member of large encoded catalyst libraries for the ability to catalyze a reaction in solution. The procedure was used to select active catalysts from a library of potential polymer-bound multifunctional catalysts. From \u223c7000 beads screened (3150 distinct catalysts), 23 beads were selected for catalysis of an acylation reaction. Kinetic experiments indicate that the most strongly selected beads are also the most efficient catalysts.<\/jats:p>","DOI":"10.1126\/science.280.5361.267","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:49:42Z","timestamp":1027763382000},"page":"267-270","source":"Crossref","is-referenced-by-count":261,"title":["Thermographic Selection of Effective Catalysts from an Encoded Polymer-Bound Library"],"prefix":"10.1126","volume":"280","author":[{"given":"Steven J.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599\u20133290, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Morken","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599\u20133290, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"6666","DOI":"10.1021\/jo00126a008","volume":"60","author":"Menger F. M.","year":"1995","unstructured":"Menger F. M., Eliseev A. V., Migulin V. A., J. Org. Chem.60, 6666 (1995).","journal-title":"J. Org. Chem."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/anie.199602201","volume":"35","author":"Lim H. J.","year":"1996","unstructured":"G. Liu and J. A. Ellman, ibid., p. 7712; K. Burgess, Lim H. J., Porte A. M., Sulikowski G., Angew. Chem. Int. Ed. Engl. 35, 220 (1996); B. M. Cole et al., ibid., p. 1668.","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1021\/ja961842u","volume":"118","author":"Francis M. B.","year":"1996","unstructured":"K. S. Lam, et al., Nature 354, 82 (1991); J. K. Chen, W. S. Lane, A. W. Brauer, A. Tanaka, S. L. Schreiber, J. Am. Chem. Soc. 115, 12591 (1993); A. Borchardt, W. C. Still, ibid 116, 373 (1994); M. T. Burger, W. C. Still, J. Org. Chem. 60, 7382 (1995); Francis M. B., Finney N. S., Jacobsen E. N., J. Am. Chem. Soc. 118, 8983 (1996); H. P. Nestler, H. Wenemers, R. Sherlock, D. L. Y. Dong, Bioorg. Med. Chem. Lett. 6, 1327 (1996).","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1039\/ft9959100991","volume":"91","author":"Eskendirov I.","year":"1995","unstructured":"I. P. Nagy, J. A. Pojman, Chem. Phys. Lett. 200, 147 (1992); K. Kustin, E. W. Ross, J. Chem. Educ. 70, 454 (1993); Eskendirov I., Kabongo B., Glasser L., Sokolovskii V. D., J. Chem. Soc. Faraday Trans. 91, 991 (1995).","journal-title":"J. Chem. Soc. Faraday Trans."},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","unstructured":"F. C. Moates et al. Ind. Eng. Chem. Res. 35 4801 (1996).","DOI":"10.1021\/ie960476k"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1021\/ja963835b","volume":"119","author":"Ruble J. C.","year":"1997","unstructured":"E. Vedejs, X. Chen, J. Am. Chem. Soc. 118, 1809 (1996); J. C. Ruble, G. C. Fu, J. Org. Chem. 61, 7230 (1996); Ruble J. C., Latham H. A., Fu G. C., J. Am. Chem. Soc. 119, 1492 (1997); T. Kawabata, M. Nagato, K. Takasu, K. Fuji, ibid., p. 3169.","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1021\/ja00061a056","volume":"115","author":"Vedejs E.","year":"1993","unstructured":"A. Fersht, W. P. Jencks, J. Am. Chem. Soc. 92, 5432 (1970); E. Guibe-Jampel, G. Le Corre, M. Wakselman,Tetrahedron Lett. 1157 (1979); G. Hofle, W. Steglich, H. Vorbruggen, Angew. Chem. Int. Ed. Engl. 17, 596 (1978); Vedejs E., Diver S. T., J. Am. Chem. Soc. 115, 3358 (1993).","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/ma00170a011","volume":"20","author":"Deratani A.","year":"1987","unstructured":"For relevant studies, see E. J. Delaney, L. E. Wood, I. M. Klotz, J. Am. Chem. Soc. 104, 799 (1982); M. Tomoi, Y. Akada, H. Kakiuchi, Makromol. Chem. Rapid Commun. 3, 537 (1982); F. M. Menger, D. J. McCann, J. Org. Chem. 50, 3928 (1985); Deratani A., Darling G. D., Horak D., Frechet J. M. J., Macromolecules 20, 767 (1987).","journal-title":"Macromolecules"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.23.10922"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1399-3011.1991.tb00765.x","volume":"37","author":"Furka A.","year":"1991","unstructured":"Furka A., Sebestyen F., Asgedom M., Dibo G., Int. J. Pept. Protein Res.37, 487 (1991).","journal-title":"Int. J. Pept. Protein Res."},{"key":"e_1_3_1_12_2","unstructured":"Library synthesis was performed on aminomethyl polystyrene macrobeads (500 \u03bcm 1.04 mmol\/g; Rapp Polymere T\u00fcbingen Germany) because catalysts on this polymer support were found to give a larger temperature increase in a related assay developed in our labs."},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1021\/ja953750v","volume":"118","author":"Combs A. P.","year":"1996","unstructured":"Combs A. P., et al., J. Am. Chem. Soc.118, 287 (1996).","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_3_1_14_2","unstructured":"B12 was prepared by treatment of l -proline tert -butyl ester (2 equiv.) and 4-bromopyridine (1 equiv.) with diisopropylethylamine (3 equiv) in dimethyl sulfoxide at 120\u00b0C for 12 hours."},{"key":"e_1_3_1_15_2","unstructured":"Synthesis efficiency or site-site interactions between multiple catalyst moieties may lead to variation in observed activity that does not reflect inherent activity. In regard to catalyst synthesis preliminary data indicate that the syntheses were successful in the preparation of 1 2 and 5. Catalyst resynthesis on Rink amide resin (Novabiochem) followed by cleavage from solid support afforded a compound with very clean low-resolution fast atom bombardment mass spectra corresponding to the predicted product in each case. Although these results are not quantitative and are somewhat ambiguous because a different resin was used in resynthesis as compared with library preparation they do indicate that no fundamental synthesis problems occurred during the preparation of these monomer sequences."},{"key":"e_1_3_1_16_2","unstructured":"J. D. Cox and G. Pilcher Thermochemistry of Organic and Organometallic Compounds (Academic Press New York 1970)."},{"key":"e_1_3_1_17_2","unstructured":"We thank L. H. Bogart of Cincinnati Electronics (Mason OH) and R. E. Richardson of Mec-Tric Control (Charlotte NC) for assistance and use of the Cincinnati Electronics IRRIS-256ST IR camera."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.280.5361.267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T05:14:06Z","timestamp":1705122846000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.280.5361.267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4,10]]},"references-count":16,"journal-issue":{"issue":"5361","published-print":{"date-parts":[[1998,4,10]]}},"alternative-id":["10.1126\/science.280.5361.267"],"URL":"https:\/\/doi.org\/10.1126\/science.280.5361.267","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4,10]]}}}