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Biological activity of v-\n            <jats:italic>sis<\/jats:italic>\n            was also abolished by either a small deletion within the coding region of the signal sequence or by a point mutation introduced by site-directed mutagenesis.\n          <\/jats:p>","DOI":"10.1126\/science.6095451","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T19:41:59Z","timestamp":1160077319000},"page":"1197-1199","source":"Crossref","is-referenced-by-count":43,"title":["Requirement for a Signal Sequence in Biological Expression of the v-\n            <i>sis<\/i>\n            Oncogene"],"prefix":"10.1126","volume":"226","author":[{"given":"Mark","family":"Hannink","sequence":"first","affiliation":[{"name":"Department of Chemistry, B-017, University of California, San Diego, La Jolla 92093"}]},{"given":"Daniel J.","family":"Donoghue","sequence":"additional","affiliation":[{"name":"Department of Chemistry, B-017, University of California, San Diego, La Jolla 92093"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0092-8674(79)90188-0","volume":"16","year":"1979","unstructured":"ANDERSSON, P, DEFINED SUB-GENOMIC FRAGMENT OF INVITRO SYNTHESIZED MOLONEY SARCOMA-VIRUS DNA CAN INDUCE CELL TRANSFORMATION UPON TRANSFECTION, CELL 16: 63 (1979).","journal-title":"CELL"},{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6310754"},{"key":"e_1_2_1_3_1","first-page":"3179","volume":"79","year":"1982","unstructured":"Devare, S. 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