{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:00:05Z","timestamp":1770480005979,"version":"3.49.0"},"reference-count":13,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4494","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>\n            Histidine-requiring mutants of\n            <jats:italic>Salmonella typhimurium<\/jats:italic>\n            TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.\n          <\/jats:p>","DOI":"10.1126\/science.6259738","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"546-547","source":"Crossref","is-referenced-by-count":198,"title":["Mutation Caused by Human Phagocytes"],"prefix":"10.1126","volume":"212","author":[{"given":"Sigmund A.","family":"Weitzman","sequence":"first","affiliation":[{"name":"Hematology-Oncology Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston 02114"}]},{"given":"Thomas P.","family":"Stossel","sequence":"additional","affiliation":[{"name":"Hematology-Oncology Unit, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston 02114"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0165-1161(80)90191-0","volume":"74","year":"1980","unstructured":"MUTATION RESEARCH 74: 71 (1980).","journal-title":"MUTATION RESEARCH"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-1161(75)90046-1","volume":"31","year":"1975","unstructured":"AMES, B.N., METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST, MUTATION RESEARCH 31: 347 (1975).","journal-title":"MUTATION RESEARCH"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI107704","volume":"53","year":"1974","unstructured":"BOXER, L.A., EFFECTS OF ANTI-HUMAN NEUTROPHIL ANTIBODIES INVITRO - QUANTITATIVE STUDIES, JOURNAL OF CLINICAL INVESTIGATION 53: 1534 (1974).","journal-title":"JOURNAL OF CLINICAL INVESTIGATION"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0165-1161(80)90239-3","volume":"74","year":"1980","unstructured":"CHELI, C, THE SALMONELLA MUTAGENICITY ASSAY - REPRODUCIBILITY, MUTATION RESEARCH 74: 145 (1980).","journal-title":"MUTATION RESEARCH"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1084\/jem.141.6.1442","volume":"141","year":"1975","unstructured":"CLARK, R.A., NEUTROPHIL-MEDIATED TUMOR-CELL CYTOTOXICITY - ROLE OF PEROXIDASE SYSTEM, JOURNAL OF EXPERIMENTAL MEDICINE 141: 1442 (1975).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM197107012850103","volume":"285","year":"1971","unstructured":"DEVROEDE, G.J., CANCER RISK AND LIFE EXPECTANCY OF CHILDREN WITH ULCERATIVE COLITIS, NEW ENGLAND JOURNAL OF MEDICINE 285: 17 (1971).","journal-title":"NEW ENGLAND JOURNAL OF MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/250667a0","volume":"250","year":"1974","unstructured":"ECCLES, S.A., MACROPHAGE CONTENT OF TUMORS IN RELATION TO METASTATIC SPREAD AND HOST IMMUNE-REACTION, NATURE 250: 667 (1974).","journal-title":"NATURE"},{"key":"e_1_2_1_8_1","first-page":"1681","year":"1980","unstructured":"Hibbs, J. B., Mononuclear Phagocytes: 1681 (1980).","journal-title":"Mononuclear Phagocytes"},{"key":"e_1_2_1_9_1","unstructured":"Klebanoff S. J. The Neutrophil: Function and Clinical Disorders (1978)."},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1021\/bi00554a029","volume":"19","year":"1980","unstructured":"LESKO, S.A., INVOLVEMENT OF POLYCYCLIC AROMATIC-HYDROCARBONS AND REDUCED OXYGEN RADICALS IN CARCINOGENESIS .5. ROLE OF SUPEROXIDE IN DEOXYRIBONUCLEIC-ACID STRAND SCISSION, BIOCHEMISTRY 19: 3023 (1980).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.766187"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1182\/blood.V52.1.211.211","volume":"52","year":"1978","unstructured":"RINEHART, J.J., HUMAN MONOCYTE-INDUCED TUMOR-CELL CYTOTOXICITY, BLOOD 52: 211 (1978).","journal-title":"BLOOD"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107801"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.6259738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T23:05:21Z","timestamp":1705273521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.6259738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5]]},"references-count":13,"journal-issue":{"issue":"4494","published-print":{"date-parts":[[1981,5]]}},"alternative-id":["10.1126\/science.6259738"],"URL":"https:\/\/doi.org\/10.1126\/science.6259738","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,5]]}}}