{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:57:49Z","timestamp":1780354669761,"version":"3.54.1"},"reference-count":40,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4514","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1981,9,18]]},"abstract":"<jats:p>\n            A peptide with high potency and intrinsic activity for stimulating the secretion of corticotropin-like and \u03b2-endorphin-like immunoactivities by cultured anterior pituitary cells has been purified from ovine hypothalamic extracts. The primary structure of this 41-residue corticotropin- and \u03b2-endorphin-releasing factor has been determined to be: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH\n            <jats:sub>2<\/jats:sub>\n            . The synthetic peptide is active in vitro and in vivo.\n          <\/jats:p>","DOI":"10.1126\/science.6267699","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T17:45:58Z","timestamp":1160070358000},"page":"1394-1397","source":"Crossref","is-referenced-by-count":3648,"title":["Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and \u03b2-Endorphin"],"prefix":"10.1126","volume":"213","author":[{"given":"Wylie","family":"Vale","sequence":"first","affiliation":[{"name":"Peptide Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Spiess","sequence":"additional","affiliation":[{"name":"Peptide Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Rivier","sequence":"additional","affiliation":[{"name":"Peptide Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rivier","sequence":"additional","affiliation":[{"name":"Peptide Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1210\/endo-81-2-235","volume":"81","year":"1967","unstructured":"ARIMURA, A, ASSAYS FOR CORTICOTROPIN-RELEASING FACTOR (CRF) USING RATS TREATED WITH MORPHINE CHLORPROMAZINE DEXAMETHASONE AND NEMBUTAL, ENDOCRINOLOGY 81: 235 (1967).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_2_1","unstructured":"Burgus R. Hypothalamus and Endocrine Functions (1976)."},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1210\/endo-85-4-644","volume":"85","year":"1969","unstructured":"CHAN, L.T., PROPERTIES OF CORTICOTROPHIN-RELEASING FACTOR OF RAT MEDIAN EMINENCE, ENDOCRINOLOGY 85: 644 (1969).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1677\/joe.0.0710171","volume":"71","year":"1976","unstructured":"COOPER, DMF, STUDIES ON NATURE OF CORTICOTROPIN RELEASING HORMONE AND ITS PARTIAL-PURIFICATION FROM PORCINE HYPOTHALAMI, JOURNAL OF ENDOCRINOLOGY 71: 171 (1976).","journal-title":"JOURNAL OF ENDOCRINOLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3181\/00379727-121-30682","volume":"121","year":"1966","unstructured":"DHARIWAL, APS, PURIFICATION OF HYPOTHALAMIC CORTICOTROPHIN-RELEASING FACTOR (CRF) OF OVINE ORIGIN, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 121: 8 (1966).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0165-6147(80)90060-7","volume":"1","year":"1980","unstructured":"ERSPAMER, V, TRENDS IN PHARMACOLOGICAL SCIENCES 1: 391 (1980).","journal-title":"TRENDS IN PHARMACOLOGICAL SCIENCES"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/278463a0","volume":"278","year":"1979","unstructured":"GILLIES, G, CORTICOTROPIN RELEASING FACTOR MAY BE MODULATED VASOPRESSIN, NATURE 278: 463 (1979).","journal-title":"NATURE"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/endo-57-5-599","volume":"57","year":"1955","unstructured":"GUILLEMIN, R, HUMORAL HYPOTHALAMIC CONTROL OF ANTERIOR PITUITARY - A STUDY WITH COMBINED TISSUE CULTURES, ENDOCRINOLOGY 57: 599 (1955).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_9_1","first-page":"89","volume":"20","year":"1964","unstructured":"GUILLEMIN, R, HYPOTHALAMIC FACTORS RELEASING PITUITARY HORMONES, RECENT PROGRESS IN HORMONE RESEARCH 20: 89 (1964).","journal-title":"RECENT PROGRESS IN HORMONE RESEARCH"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1152\/physrev.1948.28.2.139","volume":"28","year":"1948","unstructured":"HARRIS, G.W., NEURAL CONTROL OF THE PITUITARY GLAND, PHYSIOLOGICAL REVIEWS 28: 139 (1948).","journal-title":"PHYSIOLOGICAL REVIEWS"},{"key":"e_1_2_1_11_1","first-page":"2104","volume":"36","year":"1977","unstructured":"JONES, M.T., NATURE OF CORTICOTROPIN RELEASING FACTOR FROM RAT HYPOTHALAMUS INVITRO, FEDERATION PROCEEDINGS 36: 2104 (1977).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0006-291X(78)91306-2","volume":"80","year":"1978","unstructured":"KNUDSEN, R, ISOLATION OF N-ACETYLASPARTIC ACID FROM HYPOTHALAMIC TISSUE AND SIGNIFICANCE OF ITS ACTH-RELEASING ACTIVITY, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 80: 735 (1978).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_13_1","unstructured":"LEDERIS K COMMUNICATION."},{"key":"e_1_2_1_14_1","unstructured":"LEDERIS K P NATL MED CHEM S (1976)."},{"key":"e_1_2_1_15_1","first-page":"38","volume":"203","year":"1977","unstructured":"MACCANNELL, K, DILATATION OF MESENTERIC VASCULAR BED OF DOG PRODUCED BY A PEPTIDE, UROTENSIN I, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 203: 38 (1977).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1021\/ja00401a040","volume":"103","year":"1981","unstructured":"MARKI, W, TOTAL SOLID-PHASE SYNTHESIS OF PORCINE GUT GASTRIN RELEASING PEPTIDE (GRP), A MAMMALIAN BOMBESIN, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 103: 3178 (1981).","journal-title":"JOURNAL OF THE AMERICAN CHEMICAL SOCIETY"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1210\/endo-60-5-664","volume":"60","year":"1957","unstructured":"MCCANN, S.M., ACTH-RELEASING ACTIVITY OF EXTRACTS OF THE POSTERIOR LOBE OF THE PITUITARY INVIVO, ENDOCRINOLOGY 60: 664 (1957).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1021\/ja00897a025","volume":"85","year":"1963","unstructured":"MERRIFIELD, R.B., SOLID PHASE PEPTIDE SYNTHESIS .1. SYNTHESIS OF A TETRAPEPTIDE, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 85: 2149 (1963).","journal-title":"JOURNAL OF THE AMERICAN CHEMICAL SOCIETY"},{"key":"e_1_2_1_19_1","first-page":"1178","volume":"360","year":"1979","unstructured":"MONTECUCCHI, P.C., STRUCTURE OF SAUVAGINE, A VASOACTIVE PEPTIDE FROM THE SKIN OF A FROG, HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 360: 1178 (1979).","journal-title":"HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0024-3205(79)90261-3","volume":"25","year":"1979","unstructured":"OGAWA, N, BETA-ENDORPHIN CONCENTRATION IN THE BRAIN OF INTACT AND HYPOPHYSECTOMIZED RATS, LIFE SCIENCES 25: 317 (1979).","journal-title":"LIFE SCIENCES"},{"key":"e_1_2_1_21_1","first-page":"245","year":"1979","unstructured":"ORTH, D.N., METHOD HORM RADIOIMM: 245 (1979).","journal-title":"METHOD HORM RADIOIMM"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1749-6632.1977.tb41875.x","volume":"297","year":"1977","unstructured":"PALKOVITS, M, ANN NY ACAD SCI 297: 455 (1977).","journal-title":"ANN NY ACAD SCI"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3181\/00379727-143-37386","volume":"143","year":"1973","unstructured":"PORTANOVA, R, ISOLATED PITUITARY CELLS - CRF-LIKE ACTIVITY OF NEUROHYPOPHYSEAL AND RELATED POLYPEPTIDES, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 143: 661 (1973).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1210\/endo-64-6-948","volume":"64","year":"1959","unstructured":"PORTER, J.C., FURTHER STUDY OF AN ACTH-RELEASING PROTEIN FROM HYPOPHYSEAL PORTAL VESSEL PLASMA, ENDOCRINOLOGY 64: 948 (1959).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_25_1","unstructured":"RIVIER J UNPUBLISHED."},{"key":"e_1_2_1_26_1","unstructured":"Rivier J. Peptides: Synthesis-Structure-Function: 7th American Peptide Symposium (1981)."},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1139\/y55-054","volume":"33","year":"1955","unstructured":"SAFFRAN, M, THE RELEASE OF CORTICOTROPHIN BY ANTERIOR PITUITARY TISSUE INVITRO, CANADIAN JOURNAL OF BIOCHEMISTRY AND PHYSIOLOGY 33: 408 (1955).","journal-title":"CANADIAN JOURNAL OF BIOCHEMISTRY AND PHYSIOLOGY"},{"key":"e_1_2_1_28_1","first-page":"3","volume":"116","year":"1980","unstructured":"SAYERS, G, FEBS LETT 116: 3 (1980).","journal-title":"FEBS LETT"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/0006-291X(78)90914-2","volume":"82","year":"1978","unstructured":"SCHALLY, A.V., ISOLATION, STRUCTURAL ELUCIDATION AND SYNTHESIS OF A TETRADECAPEPTIDE WITH INVITRO ACTH-RELEASING ACTIVITY CORRESPONDING TO RESIDUES 33-46 OF ALPHA-CHAIN OF PORCINE HEMOGLOBIN, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 82: 582 (1978).","journal-title":"BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/1881192a0","volume":"188","year":"1960","unstructured":"Schally, A. V., Nature 188:1192 (1960).","journal-title":"Nature"},{"key":"e_1_2_1_31_1","first-page":"497","volume":"24","year":"1968","unstructured":"SCHALLY, A.V., RECENT PROGRESS IN HORMONE RESEARCH 24: 497 (1968).","journal-title":"RECENT PROGRESS IN HORMONE RESEARCH"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1084\/jem.106.3.439","volume":"106","year":"1957","unstructured":"SKEGGS, L.T., THE PREPARATION, PURIFICATION, AND AMINO ACID SEQUENCE OF A POLYPEPTIDE RENIN SUBSTRATE, JOURNAL OF EXPERIMENTAL MEDICINE 106: 439 (1957).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1021\/bi00510a038","volume":"20","year":"1981","unstructured":"SPIESS, J, ISOLATION AND SEQUENCE-ANALYSIS OF A SOMATOSTATIN-LIKE POLYPEPTIDE FROM OVINE HYPOTHALAMUS, BIOCHEMISTRY 20: 1982 (1981).","journal-title":"BIOCHEMISTRY"},{"key":"e_1_2_1_34_1","first-page":"6517","volume":"78","year":"1981","unstructured":"Spiess, J., Proceedings of the National Academy of Sciences of the United States of America 78: 6517 (1981).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1210\/endo-91-2-562","volume":"91","year":"1972","unstructured":"VALE, W, CULTURE OF ENZYMATICALLY DISPERSED ANTERIOR-PITUITARY CELLS - FUNCTIONAL VALIDATION OF A METHOD, ENDOCRINOLOGY 91: 562 (1972).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1210\/endo-103-5-1910","volume":"103","year":"1978","unstructured":"VALE, W, EFFECTS OF PURIFIED HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR AND OTHER SUBSTANCES ON SECRETION OF ADRENOCORTICOTROPIN AND BETA-ENDORPHIN-LIKE IMMUNOACTIVITIES INVITRO, ENDOCRINOLOGY 103: 1910 (1978).","journal-title":"ENDOCRINOLOGY"},{"key":"e_1_2_1_37_1","first-page":"8","volume":"36","year":"1977","unstructured":"VALE, W, FEDERATION PROCEEDINGS 36: 8 (1977).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_38_1","unstructured":"VALE W HYPOTHALAMUS ENDOCRI (1976)."},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0003-2697(76)90117-2","volume":"75","year":"1976","unstructured":"WITTMANNLIEBOLD, B, DEVICE COUPLED TO A MODIFIED SEQUENATOR FOR AUTOMATED CONVERSION OF ANILINOTHIAZOLINONES INTO PTH AMINO-ACIDS, ANALYTICAL BIOCHEMISTRY 75: 621 (1976).","journal-title":"ANALYTICAL BIOCHEMISTRY"},{"key":"e_1_2_1_40_1","unstructured":"YATES F.E. HDB PHYSL 7 4 (1974)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.6267699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T23:07:47Z","timestamp":1705273667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.6267699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9,18]]},"references-count":40,"journal-issue":{"issue":"4514","published-print":{"date-parts":[[1981,9,18]]}},"alternative-id":["10.1126\/science.6267699"],"URL":"https:\/\/doi.org\/10.1126\/science.6267699","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9,18]]}}}