{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:08:54Z","timestamp":1770973734216,"version":"3.50.1"},"reference-count":43,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4623","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1983,11,4]]},"abstract":"<jats:p>The gene for glycoprotein D of herpes simplex virus type 1 (HSV-1) was expressed in stable mammalian cell lines. Glycoprotein D produced in these cells has a number of antigenic determinants in common with the native glycoprotein. Cell lines expressing glycoprotein D were used in an enzyme-linked immunosorbent assay to detect human antibodies to glycoprotein D. This strategy should prove useful in determining the extent to which the immune response to HSV-1 is directed toward glycoprotein D.<\/jats:p>","DOI":"10.1126\/science.6312563","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T18:37:18Z","timestamp":1160073438000},"page":"524-527","source":"Crossref","is-referenced-by-count":61,"title":["Detection of Antibodies to Herpes Simplex Virus with a Continuous Cell Line Expressing Cloned Glycoprotein D"],"prefix":"10.1126","volume":"222","author":[{"given":"Phillip W.","family":"Berman","sequence":"first","affiliation":[{"name":"Department of Vaccine Development, Genentech, Inc., South San Francisco, California 94080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Dowbenko","sequence":"additional","affiliation":[{"name":"Department of Vaccine Development, Genentech, Inc., South San Francisco, California 94080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence A.","family":"Lasky","sequence":"additional","affiliation":[{"name":"Department of Vaccine Development, Genentech, Inc., South San Francisco, California 94080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian C.","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"629","volume":"82","year":"1979","unstructured":"BLOCH, R.J., J CELL BIOL 82: 629 (1979).","journal-title":"J CELL BIOL"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1128\/jvi.43.3.1061-1071.1982","volume":"43","year":"1982","unstructured":"CAMPADELLIFIUME, G, INFECTIVITY AND GLYCOPROTEIN PROCESSING OF HERPES-SIMPLEX VIRUS TYPE-1 GROWN IN A RICIN-RESISTANT CELL-LINE DEFICIENT IN N-ACETYLGLUCOSAMINYL TRANSFERASE-I, JOURNAL OF VIROLOGY 43: 1061 (1982).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/nar\/7.2.335","volume":"7","year":"1979","unstructured":"CHARNAY, P, LOCALIZATION ON THE VIRAL GENOME AND NUCLEOTIDE-SEQUENCE OF THE GENE CODING FOR THE 2 MAJOR POLYPEPTIDES OF THE HEPATITIS-B SURFACE-ANTIGEN (HBS AG), NUCLEIC ACIDS RESEARCH 7: 335 (1979).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1128\/jvi.36.2.429-439.1980","volume":"36","year":"1980","unstructured":"COHEN, G.H., SYNTHESIS AND PROCESSING OF GLYCOPROTEINS GD AND GC OF HERPES-SIMPLEX VIRUS TYPE-1, JOURNAL OF VIROLOGY 36: 429 (1980).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1128\/jvi.46.3.679-689.1983","volume":"46","year":"1983","unstructured":"COHEN, G.H., GLYCOPEPTIDES OF THE TYPE-COMMON GLYCOPROTEIN-GD OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2, JOURNAL OF VIROLOGY 46: 679 (1983).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/jvi.27.1.172-181.1978","volume":"27","year":"1978","unstructured":"COHEN, G.H., TYPE-COMMON CP-1 ANTIGEN OF HERPES-SIMPLEX VIRUS IS ASSOCIATED WITH A 59,000-MOLECULAR-WEIGHT ENVELOPE GLYCOPROTEIN, JOURNAL OF VIROLOGY 27: 172 (1978).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_7_1","first-page":"44","volume":"3","year":"1983","unstructured":"CROWLEY, C.W., PLASMID-DIRECTED SYNTHESIS OF HEPATITIS-B SURFACE-ANTIGEN IN MONKEY CELLS, MOLECULAR AND CELLULAR BIOLOGY 3: 44 (1983).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_8_1","first-page":"5376","volume":"78","year":"1981","unstructured":"DAVIS, A.R., EXPRESSION OF ANTIGENIC DETERMINANTS OF THE HEMAGGLUTININ GENE OF A HUMAN INFLUENZA-VIRUS IN ESCHERICHIA-COLI, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 5376 (1981).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/283171a0","volume":"283","year":"1980","unstructured":"EMTAGE, J.S., INFLUENZA ANTIGENIC DETERMINANTS ARE EXPRESSED FROM HEMAGGLUTININ GENES CLONED IN ESCHERICHIA-COLI, NATURE 283: 171 (1980).","journal-title":"NATURE"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/293620a0","volume":"293","year":"1981","unstructured":"GETHING, M.J., CELL-SURFACE EXPRESSION OF INFLUENZA HEMAGGLUTININ FROM A CLONED DNA COPY OF THE RNA GENE, NATURE 293: 620 (1981).","journal-title":"NATURE"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7058331"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(73)90341-3"},{"key":"e_1_2_1_13_1","first-page":"343","year":"1980","unstructured":"HERRMON, K.L., MANUAL CLIN IMMUNOLO: 343 (1980).","journal-title":"MANUAL CLIN IMMUNOLO"},{"key":"e_1_2_1_14_1","first-page":"2743","volume":"11","year":"1983","unstructured":"HITZEMAN, R.A., NUCLEIC ACIDS RES 11: 2743 (1983).","journal-title":"NUCLEIC ACIDS RES"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1128\/jvi.16.5.1308-1326.1975","volume":"16","year":"1975","unstructured":"HONESS, R.W., PROTEINS SPECIFIED BY HERPES-SIMPLEX VIRUS .13. GLYCOSYLATION OF VIRAL POLYPEPTIDES, JOURNAL OF VIROLOGY 16: 1308 (1975).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(83)90083-1","volume":"32","year":"1983","unstructured":"JOHNSON, D.C., O-LINKED OLIGOSACCHARIDES ARE ACQUIRED BY HERPES-SIMPLEX VIRUS GLYCOPROTEINS IN THE GOLGI-APPARATUS, CELL 32: 987 (1983).","journal-title":"CELL"},{"key":"e_1_2_1_17_1","first-page":"376","year":"1980","unstructured":"KENNETT, R.H., MONOCLONAL ANTIBODIE: 376 (1980).","journal-title":"MONOCLONAL ANTIBODIE"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.115.6.1617","volume":"115","year":"1975","unstructured":"KESSLER, S.W., RAPID ISOLATION OF ANTIGENS FROM CELLS WITH A STAPHYLOCOCCAL PROTEIN A-ANTIBODY ADSORBENT - PARAMETERS OF INTERACTION OF ANTIBODY-ANTIGEN COMPLEXES WITH PROTEIN-A, JOURNAL OF IMMUNOLOGY 115: 1617 (1975).","journal-title":"JOURNAL OF IMMUNOLOGY"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6272395"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/289555a0","volume":"289","year":"1981","unstructured":"KUPPER, H, CLONING OF CDNA OF MAJOR ANTIGEN OF FOOT AND MOUTH-DISEASE VIRUS AND EXPRESSION IN ESCHERICHIA-COLI, NATURE 289: 555 (1981).","journal-title":"NATURE"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_22_1","unstructured":"LASKY L unpublished data."},{"key":"e_1_2_1_23_1","unstructured":"LASKY L.A. unpublished data."},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1128\/jvi.43.1.41-49.1982","volume":"43","year":"1982","unstructured":"LEE, GTY, LOCATION OF THE STRUCTURAL GENES FOR GLYCOPROTEINS GD AND GE AND FOR OTHER POLYPEPTIDES IN THE S COMPONENT OF HERPES-SIMPLEX VIRUS TYPE-1 DNA, JOURNAL OF VIROLOGY 43: 41 (1982).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/293079a0","volume":"293","year":"1981","unstructured":"LUSKY, M, INHIBITION OF SV40 REPLICATION IN SIMIAN CELLS BY SPECIFIC PBR322 DNA-SEQUENCES, NATURE 293: 79 (1981).","journal-title":"NATURE"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/nar\/9.2.309","volume":"9","year":"1981","unstructured":"MESSING, J, A SYSTEM FOR SHOTGUN DNA SEQUENCING, NUCLEIC ACIDS RESEARCH 9: 309 (1981).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0092-8674(80)90510-3","volume":"19","year":"1980","unstructured":"NUNBERG, J.H., STRUCTURE AND GENOMIC ORGANIZATION OF THE MOUSE DIHYDROFOLATE-REDUCTASE GENE, CELL 19: 355 (1980).","journal-title":"CELL"},{"key":"e_1_2_1_28_1","first-page":"5202","volume":"78","year":"1981","unstructured":"Pereira, L., Proceedings of the National Academy of Sciences of the United States of America 78: 5202 (1981).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/iai.38.1.168-174.1982","volume":"38","year":"1982","unstructured":"RECTOR, J.T., USE OF MONOCLONAL-ANTIBODIES FOR ANALYSIS OF ANTIBODY-DEPENDENT IMMUNITY TO OCULAR HERPES-SIMPLEX VIRUS TYPE-1 INFECTION, INFECTION AND IMMUNITY 38: 168 (1982).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0092-8674(82)90280-X","volume":"30","year":"1982","unstructured":"ROSE, J.K., EXPRESSION FROM CLONED CDNA OF CELL-SURFACE SECRETED FORMS OF THE GLYCOPROTEIN OF VESICULAR STOMATITIS-VIRUS IN EUKARYOTIC CELLS, CELL 30: 753 (1982).","journal-title":"CELL"},{"key":"e_1_2_1_31_1","first-page":"6670","volume":"78","year":"1981","unstructured":"Rose, J. K., Proceedings of the National Academy of Sciences of the United States of America 78: 6670 (1981).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1128\/jvi.29.2.677-697.1979","volume":"29","year":"1979","unstructured":"RUYECHAN, W.T., MOLECULAR GENETICS OF HERPES-SIMPLEX VIRUS .2. MAPPING OF THE MAJOR VIRAL GLYCOPROTEINS AND OF THE GENETIC LOCI SPECIFYING THE SOCIAL-BEHAVIOR OF INFECTED-CELLS, JOURNAL OF VIROLOGY 29: 677 (1979).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.12.5463"},{"key":"e_1_2_1_34_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/iai.34.3.684-692.1981","volume":"34","year":"1981","unstructured":"SHOWALTER, S.D., MONOCLONAL-ANTIBODIES TO HERPES-SIMPLEX VIRUS TYPE-1 PROTEINS, INCLUDING THE IMMEDIATE-EARLY PROTEIN ICP-4, INFECTION AND IMMUNITY 34: 684 (1981).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1099\/0022-1317-19-2-217","volume":"19","year":"1973","unstructured":"SIM, C, ROLE OF TYPE SPECIFIC AND CROSS REACTING STRUCTURAL ANTIGENS IN NEUTRALIZATION OF HERPES-SIMPLEX VIRUS TYPES 1 AND 2, JOURNAL OF GENERAL VIROLOGY 19: 217 (1973).","journal-title":"JOURNAL OF GENERAL VIROLOGY"},{"key":"e_1_2_1_36_1","first-page":"2495","volume":"80","year":"1983","unstructured":"Simonsen, C. C., Proceedings of the National Academy of Sciences of the United States of America 80: 2495 (1983).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1128\/jvi.17.3.991-1008.1976","volume":"17","year":"1976","unstructured":"SPEAR, P.G., MEMBRANE PROTEINS SPECIFIED BY HERPES-SIMPLEX VIRUSES .1. IDENTIFICATION OF 4 GLYCOPROTEIN PRECURSORS AND THEIR PRODUCTS IN TYPE-1 INFECTED-CELLS, JOURNAL OF VIROLOGY 17: 991 (1976).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_38_1","first-page":"4216","volume":"77","year":"1980","unstructured":"Urlaub, G., Proceedings of the National Academy of Sciences of the United States of America 77: 4216 (1980).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/298347a0","volume":"298","year":"1982","unstructured":"VALENZUELA, P, SYNTHESIS AND ASSEMBLY OF HEPATITIS-B VIRUS SURFACE-ANTIGEN PARTICLES IN YEAST, NATURE 298: 347 (1982).","journal-title":"NATURE"},{"key":"e_1_2_1_40_1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/nar\/11.5.1507","volume":"11","year":"1983","unstructured":"WATSON, R.J., CHARACTERIZATION OF THE HERPES-SIMPLEX VIRUS TYPE-1 GLYCOPROTEIN-D MESSENGER-RNA AND EXPRESSION OF THIS PROTEIN IN XENOPUS OOCYTES, NUCLEIC ACIDS RESEARCH 11: 1507 (1983).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6289440"},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/292851a0","volume":"292","year":"1981","unstructured":"WEILAND, I, NATURE 292: 851 (1981).","journal-title":"NATURE"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6297004"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.6312563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T22:55:14Z","timestamp":1705272914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.6312563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11,4]]},"references-count":43,"journal-issue":{"issue":"4623","published-print":{"date-parts":[[1983,11,4]]}},"alternative-id":["10.1126\/science.6312563"],"URL":"https:\/\/doi.org\/10.1126\/science.6312563","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,11,4]]}}}