{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:16:14Z","timestamp":1770959774155,"version":"3.50.1"},"reference-count":14,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4356","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1978,8,18]]},"abstract":"<jats:p>\n            Cytoplasmic extracts of proliferating cells stimulate DNA synthesis in isolated nuclei of\n            <jats:italic>Xenopus laevis<\/jats:italic>\n            liver. When tested by the same assay, cytoplasmic extracts of resting cells are completely inactive. When cytoplasmic extracts are prepared from cell cycle-specific temperature-sensitive mutants arrested in the G\n            <jats:sub>1<\/jats:sub>\n            phase of the cell cycle by the nonpermissive temperature, they also fail to stimulate DNA synthesis in frog nuclei. The results indicate that, to stimulate DNA synthesis in isolated frog nuclei, essentially all information of G\n            <jats:sub>1<\/jats:sub>\n            cells must be present.\n          <\/jats:p>","DOI":"10.1126\/science.675253","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T16:35:25Z","timestamp":1160066125000},"page":"651-652","source":"Crossref","is-referenced-by-count":13,"title":["Stimulated DNA Synthesis in Frog Nuclei by Cytoplasmic Extracts of Temperature-Sensitive Mammalian Cells"],"prefix":"10.1126","volume":"201","author":[{"given":"Joanna","family":"Floros","sequence":"first","affiliation":[{"name":"Fels Research Institute and Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Chang","sequence":"additional","affiliation":[{"name":"Fels Research Institute and Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Baserga","sequence":"additional","affiliation":[{"name":"Fels Research Institute and Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jcp.1040960103","volume":"96","year":"1978","unstructured":"ASHIHARA, T, CONSTANCY OF SHIFT-UP POINT IN 2 TEMPERATURE-SENSITIVE MAMMALIAN-CELL LINES THAT ARREST IN G1, JOURNAL OF CELLULAR PHYSIOLOGY 96: 15 (1978).","journal-title":"JOURNAL OF CELLULAR PHYSIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jcp.1040840308","volume":"84","year":"1974","unstructured":"BURSTIN, S.J., TEMPERATURE-SENSITIVE CELL-CYCLE MUTANT OF BHK CELL LINE, JOURNAL OF CELLULAR PHYSIOLOGY 84: 397 (1974).","journal-title":"JOURNAL OF CELLULAR PHYSIOLOGY"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01539238","volume":"2","year":"1976","unstructured":"DUBBS, D.R., REACTIVATION OF CHICK ERYTHROCYTE NUCLEI IN HETEROKARYONS WITH TEMPERATURE-SENSITIVE CHINESE-HAMSTER CELLS, SOMATIC CELL GENETICS 2: 11 (1976).","journal-title":"SOMATIC CELL GENETICS"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0309-1651(78)90006-1","volume":"2","year":"1978","unstructured":"Floros, J., Cell Biology International Reports 2: 259 (1978).","journal-title":"Cell Biology International Reports"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.183.4120.46"},{"key":"e_1_2_1_6_1","first-page":"2231","volume":"73","year":"1976","unstructured":"JAZWINSKI, S.M., INITIATION OF REPLICATION IN CHROMOSOMAL DNA INDUCED BY EXTRACTS FROM PROLIFERATING CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 2231 (1976).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_7_1","first-page":"3933","volume":"73","year":"1976","unstructured":"JAZWINSKI, S.M., ACTIVITY OF YEAST EXTRACTS IN CELL-FREE STIMULATION OF DNA-REPLICATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 3933 (1976).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jcp.1040970209","volume":"97","year":"1978","unstructured":"Lipsich, L. A., Journal of Cellular Physiology 97: 199 (1978).","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_1_9_1","first-page":"66","volume":"239","year":"1972","unstructured":"MEISS, H. K., NATURE-NEW BIOLOGY 239: 66 (1972).","journal-title":"NATURE-NEW BIOLOGY"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/jcp.1040820302","volume":"82","year":"1973","unstructured":"ROSCOE, D.H., ISOLATION OF TEMPERATURE SENSITIVE MAMMALIAN-CELLS BY SELECTIVE DETACHMENT, JOURNAL OF CELLULAR PHYSIOLOGY 82: 325 (1973).","journal-title":"JOURNAL OF CELLULAR PHYSIOLOGY"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jcp.1040840114","volume":"84","year":"1974","unstructured":"SMITH, B.J., STUDIES ON A CHINESE-HAMSTER LINE THAT IS TEMPERATURE SENSITIVE FOR COMMITMENT TO DNA-SYNTHESIS, JOURNAL OF CELLULAR PHYSIOLOGY 84: 127 (1974).","journal-title":"JOURNAL OF CELLULAR PHYSIOLOGY"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jcp.1040820304","volume":"82","year":"1973","unstructured":"SMITH, B.J., TEMPERATURE-SENSITIVE FUNCTION IN A CHINESE-HAMSTER LINE AFFECTING DNA-SYNTHESIS, JOURNAL OF CELLULAR PHYSIOLOGY 82: 339 (1973).","journal-title":"JOURNAL OF CELLULAR PHYSIOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jcp.1040920310","volume":"92","year":"1977","unstructured":"TALAVERA, A, TEMPERATURE SENSITIVE MUTANTS OF BHK CELLS AFFECTED IN CELL-CYCLE PROGRESSION, JOURNAL OF CELLULAR PHYSIOLOGY 92: 425 (1977).","journal-title":"JOURNAL OF CELLULAR PHYSIOLOGY"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0014-4827(78)90376-2","volume":"113","year":"1978","unstructured":"TSUTSUI, Y, FAILURE OF REACTIVATION OF CHICK ERYTHROCYTES AFTER FUSION WITH TEMPERATURE-SENSITIVE MUTANTS OF MAMMALIAN-CELLS ARRESTED IN G1, EXPERIMENTAL CELL RESEARCH 113: 359 (1978).","journal-title":"EXPERIMENTAL CELL RESEARCH"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.675253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T21:42:31Z","timestamp":1705268551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.675253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,8,18]]},"references-count":14,"journal-issue":{"issue":"4356","published-print":{"date-parts":[[1978,8,18]]}},"alternative-id":["10.1126\/science.675253"],"URL":"https:\/\/doi.org\/10.1126\/science.675253","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,8,18]]}}}