{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:52:09Z","timestamp":1779357129483,"version":"3.51.4"},"reference-count":33,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5219","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1995,6,30]]},"abstract":"<jats:p>\n            A\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            strain (UCBPP-PA14) is infectious both in an Arabidopsis thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 exhibits ecotype specificity for\n            <jats:italic>Arabidopsis<\/jats:italic>\n            , causing a range of symptoms from none to severe in four different ecotypes. In the mouse model, UCBPP-PA14 is as lethal as other well-studied\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            strains. Mutations in the UCBPP-PA14\n            <jats:italic>toxA<\/jats:italic>\n            ,\n            <jats:italic>plcS<\/jats:italic>\n            , and\n            <jats:italic>gacA<\/jats:italic>\n            genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals.\n          <\/jats:p>","DOI":"10.1126\/science.7604262","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1899-1902","source":"Crossref","is-referenced-by-count":1188,"title":["Common Virulence Factors for Bacterial Pathogenicity in Plants and Animals"],"prefix":"10.1126","volume":"268","author":[{"given":"Laurence G.","family":"Rahme","sequence":"first","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02114, USA."},{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA."},{"name":"Shriners Burns Institute, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily J.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Shriners Burns Institute, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean F.","family":"Wolfort","sequence":"additional","affiliation":[{"name":"Shriners Burns Institute, Massachusetts General Hospital, Boston, MA 02114, USA."},{"name":"Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02114, USA."},{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald G.","family":"Tompkins","sequence":"additional","affiliation":[{"name":"Shriners Burns Institute, Massachusetts General Hospital, Boston, MA 02114, USA."},{"name":"Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick M.","family":"Ausubel","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02114, USA."},{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA."},{"name":"Shriners Burns Institute, Massachusetts General Hospital, Boston, MA 02114, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1128\/jb.152.1.239-245.1982","volume":"152","year":"1982","unstructured":"BERKA, R.M., PHOSPHOLIPASE-C (HEAT-LABILE HEMOLYSIN) OF PSEUDOMONAS-AERUGINOSA - PURIFICATION AND PRELIMINARY CHARACTERIZATION, JOURNAL OF BACTERIOLOGY 152: 239 (1982).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/clinids\/5.2.279","volume":"5","year":"1983","unstructured":"BODEY, G.P., INFECTIONS CAUSED BY PSEUDOMONAS-AERUGINOSA, REVIEWS OF INFECTIOUS DISEASES 5: 279 (1983).","journal-title":"REVIEWS OF INFECTIOUS DISEASES"},{"key":"e_1_2_1_3_1","first-page":"115","volume":"40","year":"1950","unstructured":"BURKHOLDER, W.H., SOUR SKIN, A BACTERIAL ROT OF ONION BULBS, PHYTOPATHOLOGY 40: 115 (1950).","journal-title":"PHYTOPATHOLOGY"},{"key":"e_1_2_1_4_1","first-page":"425","volume":"65","year":"1974","unstructured":"CHO, J.J., PHYTOPATHOLOGY 65: 425 (1974).","journal-title":"PHYTOPATHOLOGY"},{"key":"e_1_2_1_5_1","first-page":"705","year":"1994","unstructured":"Crute, I., Arabidopsis: 705 (1994).","journal-title":"Arabidopsis"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1094\/MPMI-4-477","volume":"4","year":"1991","unstructured":"DAVIS, K. R., MOLECULAR PLANT-MICROBE INTERACTIONS 4: 477 (1991).","journal-title":"MOLECULAR PLANT-MICROBE INTERACTIONS"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1046\/j.1365-313X.1991.t01-7-00999.x","volume":"1","year":"1991","unstructured":"DEBENER, T, PLANT JOURNAL 1: 289 (1991).","journal-title":"PLANT JOURNAL"},{"key":"e_1_2_1_8_1","first-page":"61","volume":"3","year":"1991","unstructured":"DONG, X.N., INDUCTION OF ARABIDOPSIS DEFENSE GENES BY VIRULENT AND AVIRULENT PSEUDOMONAS-SYRINGAE STRAINS AND BY A CLONED AVIRULENCE GENE, PLANT CELL 3: 61 (1991).","journal-title":"PLANT CELL"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/jb.44.6.633-645.1942","volume":"44","year":"1942","unstructured":"Elrod, R. P., Journal of Bacteriology 44: 633 (1942).","journal-title":"Journal of Bacteriology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1094\/MPMI-5-390","volume":"5","year":"1992","unstructured":"FENSELAU, S, MOLECULAR PLANT-MICROBE INTERACTIONS 5: 390 (1992).","journal-title":"MOLECULAR PLANT-MICROBE INTERACTIONS"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1094\/MPMI-7-0455","volume":"7","year":"1994","unstructured":"GAFFNEY, T.D., MOLECULAR PLANT-MICROBE INTERACTIONS 7: 455 (1994).","journal-title":"MOLECULAR PLANT-MICROBE INTERACTIONS"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1094\/MPMI-5-384","volume":"5","year":"1992","unstructured":"GOUGH, C. L., MOLECULAR PLANT-MICROBE INTERACTIONS 5: 384 (1992).","journal-title":"MOLECULAR PLANT-MICROBE INTERACTIONS"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0378-1119(80)90069-4","volume":"11","year":"1980","unstructured":"HOHN, B, A SMALL COSMID FOR EFFICIENT CLONING OF LARGE DNA FRAGMENTS, GENE 11: 291 (1980).","journal-title":"GENE"},{"key":"e_1_2_1_14_1","first-page":"572","volume":"13","year":"1955","unstructured":"HOLLOWAY, B.W., GENETIC RECOMBINATION IN PSEUDOMONAS-AERUGINOSA, JOURNAL OF GENERAL MICROBIOLOGY 13: 572 (1955).","journal-title":"JOURNAL OF GENERAL MICROBIOLOGY"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"6878","DOI":"10.1128\/jb.174.21.6878-6885.1992","volume":"174","year":"1992","unstructured":"HUANG, H.C., THE PSEUDOMONAS-SYRINGAE PV SYRINGAE-61 HRPH PRODUCT, AN ENVELOPE PROTEIN REQUIRED FOR ELICITATION OF THE HYPERSENSITIVE RESPONSE IN PLANTS, JOURNAL OF BACTERIOLOGY 174: 6878 (1992).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1094\/MPMI-6-515","volume":"6","year":"1993","unstructured":"HUANG, H. C., MOLECULAR PLANT-MICROBE INTERACTIONS 6: 515 (1993).","journal-title":"MOLECULAR PLANT-MICROBE INTERACTIONS"},{"key":"e_1_2_1_17_1","first-page":"2284","volume":"72","year":"1975","unstructured":"IGLEWSKI, B.H., NAD-DEPENDENT INHIBITION OF PROTEIN-SYNTHESIS BY PSEUDOMONAS-AERUGINOSA TOXIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 2284 (1975).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_18_1","first-page":"1954","volume":"86","year":"1989","unstructured":"ISHIMOTO, K.S., FORMATION OF PILIN IN PSEUDOMONAS-AERUGINOSA REQUIRES THE ALTERNATIVE SIGMA-FACTOR (RPON) OF RNA-POLYMERASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 1954 (1989).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1128\/am.24.4.567-570.1972","volume":"24","year":"1972","unstructured":"KOMINOS, S.D., INTRODUCTION OF PSEUDOMONAS-AERUGINOSA INTO A HOSPITAL VIA VEGETABLES, APPLIED MICROBIOLOGY 24: 567 (1972).","journal-title":"APPLIED MICROBIOLOGY"},{"key":"e_1_2_1_20_1","first-page":"1562","volume":"89","year":"1992","unstructured":"LAVILLE, J, GLOBAL CONTROL IN PSEUDOMONAS-FLUORESCENS MEDIATING ANTIBIOTIC-SYNTHESIS AND SUPPRESSION OF BLACK ROOT-ROT OF TOBACCO, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 1562 (1992).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/0092-8674(93)90271-Q","volume":"73","year":"1993","unstructured":"LONG, S.R., PROKARYOTIC PLANT PARASITES, CELL 73: 921 (1993).","journal-title":"CELL"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-1119(83)90068-9","volume":"22","year":"1983","unstructured":"LORY, S, CHARACTERIZATION OF THE PHOSPHOLIPASE-C GENE OF PSEUDOMONAS-AERUGINOSA CLONED IN ESCHERICHIA-COLI, GENE 22: 95 (1983).","journal-title":"GENE"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1128\/jb.170.2.714-719.1988","volume":"170","year":"1988","unstructured":"LORY, S, EXPRESSION AND SECRETION OF THE CLONED PSEUDOMONAS-AERUGINOSA EXOTOXIN-A BY ESCHERICHIA-COLI, JOURNAL OF BACTERIOLOGY 170: 714 (1988).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7326\/0003-4819-76-1-9","volume":"76","year":"1972","unstructured":"MEYERS, B.R., INFECTIONS CAUSED BY MICROORGANISMS OF GENUS ERWINIA, ANNALS OF INTERNAL MEDICINE 76: 9 (1972).","journal-title":"ANNALS OF INTERNAL MEDICINE"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1128\/iai.28.3.899-908.1980","volume":"28","year":"1980","unstructured":"OHMAN, D.E., TOXIN A-DEFICIENT MUTANTS OF PSEUDOMONAS-AERUGINOSA PA103 - ISOLATION AND CHARACTERIZATION, INFECTION AND IMMUNITY 28: 899 (1980).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1128\/iai.57.5.1369-1373.1989","volume":"57","year":"1989","unstructured":"OSTROFF, R.M., MUTATIONS IN THE HEMOLYTIC-PHOSPHOLIPASE-C OPERON RESULT IN DECREASED VIRULENCE OF PSEUDOMONAS-AERUGINOSA PAO1 GROWN UNDER PHOSPHATE-LIMITING CONDITIONS, INFECTION AND IMMUNITY 57: 1369 (1989).","journal-title":"INFECTION AND IMMUNITY"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1128\/jb.169.10.4597-4601.1987","volume":"169","year":"1987","unstructured":"OSTROFF, R.M., IDENTIFICATION OF A NEW PHOSPHOLIPASE-C ACTIVITY BY ANALYSIS OF AN INSERTIONAL MUTATION IN THE HEMOLYTIC PHOSPHOLIPASE-C STRUCTURAL GENE OF PSEUDOMONAS-AERUGINOSA, JOURNAL OF BACTERIOLOGY 169: 4597 (1987).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/jb.173.2.575-586.1991","volume":"173","year":"1991","unstructured":"Rahme, L. G., Journal of Bacteriology 173: 575 (1991).","journal-title":"Journal of Bacteriology"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"7468","DOI":"10.1128\/jb.176.24.7468-7475.1994","volume":"176","year":"1994","unstructured":"RICH, J.J., GENETIC-EVIDENCE THAT THE GACA GENE ENCODES THE COGNATE RESPONSE REGULATOR FOR THE LEMA SENSOR IN PSEUDOMONAS-SYRINGAE, JOURNAL OF BACTERIOLOGY 176: 7468 (1994).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_30_1","doi-asserted-by":"crossref","first-page":"6204","DOI":"10.1128\/jb.172.11.6204-6216.1990","volume":"172","year":"1990","unstructured":"ROBERTS, R.C., GENETIC-CHARACTERIZATION OF THE STABILIZING FUNCTIONS OF A REGION OF BROAD-HOST-RANGE PLASMID RK2, JOURNAL OF BACTERIOLOGY 172: 6204 (1990).","journal-title":"JOURNAL OF BACTERIOLOGY"},{"key":"e_1_2_1_31_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0147-619X(87)90081-3","volume":"18","year":"1987","unstructured":"RUBIN, R.A., GENETIC-ANALYSIS OF THE GENTAMICIN RESISTANCE REGION OF PPH1JL AND INCORPORATION INTO A WIDE HOST RANGE CLONING VEHICLE, PLASMID 18: 84 (1987).","journal-title":"PLASMID"},{"key":"e_1_2_1_32_1","first-page":"1","year":"1977","unstructured":"Schroth, M. N., Pseudomonas aeruginosa: Ecological Aspects and Patient Colonization: 1 (1977).","journal-title":"Pseudomonas aeruginosa: Ecological Aspects and Patient Colonization"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00004630-199405000-00005","volume":"15","year":"1994","unstructured":"STEVENS, E.J., J BURN CARE REHABIL 15: 232 (1994).","journal-title":"J BURN CARE REHABIL"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.7604262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T04:49:19Z","timestamp":1705294159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.7604262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6,30]]},"references-count":33,"journal-issue":{"issue":"5219","published-print":{"date-parts":[[1995,6,30]]}},"alternative-id":["10.1126\/science.7604262"],"URL":"https:\/\/doi.org\/10.1126\/science.7604262","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6,30]]}}}