{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:03:34Z","timestamp":1781586214140,"version":"3.54.5"},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5219","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1995,6,30]]},"abstract":"<jats:p>\n            In normal\n            <jats:italic>Drosophila melanogaster<\/jats:italic>\n            oocytes, meiosis arrests at metaphase I and resumes after oocyte passage through the oviduct. Thus, metaphase arrest defines a control point in the meiotic cell cycle. Metaphase arrest only occurs in oocytes that have undergone at least one meiotic exchange. Here it is shown that crossovers between homologs attached to the same centromere do not induce metaphase arrest. Hence, exchanges induce metaphase arrest only when they physically conjoin two separate kinetochores. Thus, the signal that mediates metaphase arrest is not the exchange event per se but the resulting tension on homologous kinetochores.\n          <\/jats:p>","DOI":"10.1126\/science.7604267","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T18:19:42Z","timestamp":1161973182000},"page":"1917-1919","source":"Crossref","is-referenced-by-count":52,"title":["Induction of Metaphase Arrest in\n            <i>Drosophila<\/i>\n            Oocytes by Chiasma-Based Kinetochore Tension"],"prefix":"10.1126","volume":"268","author":[{"given":"Janet Ko","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B.","family":"Erdman","sequence":"additional","affiliation":[{"name":"Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Arbel","sequence":"additional","affiliation":[{"name":"Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Scott","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Genetics, Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1242\/dev.116.2.405","volume":"116","year":"1992","unstructured":"COURTOT, C, THE DROSOPHILA CDC25 HOMOLOG TWINE IS REQUIRED FOR MEIOSIS, DEVELOPMENT 116: 405 (1992).","journal-title":"DEVELOPMENT"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.122.6.1311","volume":"122","year":"1993","unstructured":"GORBSKY, G.J., DIFFERENTIAL EXPRESSION OF A PHOSPHOEPITOPE AT THE KINETOCHORES OF MOVING CHROMOSOMES, JOURNAL OF CELL BIOLOGY 122: 1311 (1993).","journal-title":"JOURNAL OF CELL BIOLOGY"},{"key":"e_1_2_1_3_1","first-page":"440","volume":"13","year":"1993","unstructured":"HAWLEY, R.S., DEV GENET 13: 440 (1993).","journal-title":"DEV GENET"},{"key":"e_1_2_1_4_1","first-page":"529","year":"1976","unstructured":"Holm, D. 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