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Bath application of serotonin produced a much greater elevation of [cAMP] in the processes than in the central bodies of the neurons. The resulting gradients must drive a sizable centripetal flux of cAMP because direct microinjection of cAMP showed that it diffused readily. Perinuclear increases in [cAMP] slowly caused the translocation of the freed catalytic subunit into the nucleus to an extent proportional to the percentage of its dissociation from the regulatory subunit.\n          <\/jats:p>","DOI":"10.1126\/science.7682336","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"222-226","source":"Crossref","is-referenced-by-count":454,"title":["Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in\n            <i>Aplysia<\/i>\n            Sensory Neurons"],"prefix":"10.1126","volume":"260","author":[{"given":"Brian J.","family":"Bacskai","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0647."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binyamin","family":"Hochner","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons of Columbia University, Center for Neurobiology and Behavior, New York, NY 10032."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyn","family":"Mahaut-Smith","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0647."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Adams","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0647."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong-Kiun","family":"Kaang","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons of Columbia University, Center for Neurobiology and Behavior, New York, NY 10032."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Kandel","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons of Columbia University, Center for Neurobiology and Behavior, New York, NY 10032."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger Y.","family":"Tsien","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0647."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"133","year":"1993","unstructured":"Adams, S. 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