{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:15:54Z","timestamp":1779344154563,"version":"3.51.4"},"reference-count":25,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5117","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1993,7,2]]},"abstract":"<jats:p>\n            The diversity of the T cell receptor repertoire is generated by rearrangement of gene elements in immature thymocytes. To identify a thymic signal that induces this rearrangement, a variety of agents were tested for their ability to induce rearrangement of the T cell receptor \u03b2 gene in suspensions of thymocytes from mouse embryos at day 14 of gestation. Of 16 agents tested, only interleukin-7 (IL-7) induced V(D)J gene rearrangement and sustained expression of the\n            <jats:italic>RAG-1<\/jats:italic>\n            and\n            <jats:italic>RAG-2<\/jats:italic>\n            genes, which are known to control rearrangement. These data implicate IL-7, a cytokine that is abundantly expressed in embryonic thymus, in driving gene rearrangement during early T cell development.\n          <\/jats:p>","DOI":"10.1126\/science.7686307","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"93-95","source":"Crossref","is-referenced-by-count":150,"title":["Interleukin-7: a Cofactor For V(D)J Rearrangement of the T Cell Receptor \u03b2 Gene"],"prefix":"10.1126","volume":"261","author":[{"given":"K.","family":"Muegge","sequence":"first","affiliation":[{"name":"Biological Carcinogenesis and Development Program, Program Resources Inc.\/Dyncorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702 and Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, National Cancer Institute, Frederick, MD 21702."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Vila","sequence":"additional","affiliation":[{"name":"Biological Carcinogenesis and Development Program, Program Resources Inc.\/Dyncorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702 and Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, National Cancer Institute, Frederick, MD 21702."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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