{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:26:57Z","timestamp":1776324417787,"version":"3.50.1"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5133","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1993,10,22]]},"abstract":"<jats:p>\n            Fragile X syndrome is the result of transcriptional suppression of the gene\n            <jats:italic>FMR1<\/jats:italic>\n            as a result of a trinucleotide repeat expansion mutation. The normal function of the\n            <jats:italic>FMR1<\/jats:italic>\n            protein (FMRP) and the mechanism by which its absence leads to mental retardation are unknown. Ribonucleoprotein particle (RNP) domains were identified within FMRP, and RNA was shown to bind in stoichiometric ratios, which suggests that there are two RNA binding sites per FMRP molecule. FMRP was able to bind to its own message with high affinity (dissociation constant = 5.7 nM) and interacted with approximately 4 percent of human fetal brain messages. The absence of the normal interaction of FMRP with a subset of RNA molecules might result in the pleiotropic phenotype associated with fragile X syndrome.\n          <\/jats:p>","DOI":"10.1126\/science.7692601","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T23:05:09Z","timestamp":1160089509000},"page":"563-566","source":"Crossref","is-referenced-by-count":580,"title":["<i>FMR1<\/i>\n            Protein: Conserved RNP Family Domains and Selective RNA Binding"],"prefix":"10.1126","volume":"262","author":[{"suffix":"Jr.","given":"Claude T.","family":"Ashley","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322."}]},{"given":"Keith D.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322."}]},{"given":"Daniel","family":"Reines","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322."}]},{"given":"Stephen T.","family":"Warren","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Departments of Biochemistry and Pediatrics, Emory University School of Medicine, Atlanta, GA 30322."}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/ng0793-244","volume":"4","year":"1993","unstructured":"ASHLEY, C.T., HUMAN AND MURINE FMR-1 - ALTERNATIVE SPLICING AND TRANSLATIONAL INITIATION DOWNSTREAM OF THE CGG-REPEAT, NATURE GENETICS 4: 244 (1993).","journal-title":"NATURE GENETICS"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(93)90577-D","volume":"72","year":"1993","unstructured":"BOELENS, W.C., THE HUMAN U1 SNRNP-SPECIFIC U1A PROTEIN INHIBITS POLYADENYLATION OF ITS OWN PREMESSENGER RNA, CELL 72: 881 (1993).","journal-title":"CELL"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0014-5793(79)80531-1","volume":"106","year":"1979","unstructured":"BRAUER, D, PRIMARY STRUCTURE OF PROTEIN-S3 FROM THE SMALL RIBOSOMAL-SUBUNIT OF ESCHERICHIA-COLI, FEBS LETTERS 106: 352 (1979).","journal-title":"FEBS LETTERS"},{"key":"e_1_2_1_4_1","first-page":"175","volume":"47","year":"1990","unstructured":"BROWN, W.T., INVITED EDITORIAL - THE FRAGILE-X - PROGRESS TOWARD SOLVING THE PUZZLE, AMERICAN JOURNAL OF HUMAN GENETICS 47: 175 (1990).","journal-title":"AMERICAN JOURNAL OF HUMAN GENETICS"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1399-0004.1991.tb03041.x","volume":"39","year":"1991","unstructured":"BUTLER, M.G., A 15-ITEM CHECKLIST FOR SCREENING MENTALLY-RETARDED MALES FOR THE FRAGILE X-SYNDROME, CLINICAL GENETICS 39: 347 (1991).","journal-title":"CLINICAL GENETICS"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng0193-31","volume":"3","year":"1993","unstructured":"DEBOULLE, K, A POINT MUTATION IN THE FMR-1 GENE ASSOCIATED WITH FRAGILE-X MENTAL-RETARDATION, NATURE GENETICS 3: 31 (1993).","journal-title":"NATURE GENETICS"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"9213","DOI":"10.1093\/nar\/14.22.9213","volume":"14","year":"1986","unstructured":"DELAHODDE, A, A YEAST PROTEIN HX HAS HOMOLOGIES WITH THE HISTONE H2AF EXPRESSED IN CHICKEN-EMBRYO, NUCLEIC ACIDS RESEARCH 14: 9213 (1986).","journal-title":"NUCLEIC ACIDS RESEARCH"},{"key":"e_1_2_1_8_1","first-page":"3818","volume":"79","year":"1982","unstructured":"Eilat, D., Proceedings of the National Academy of Sciences of the United States of America 79: 3818 (1982).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_1_9_1","first-page":"2379","volume":"10","year":"1990","unstructured":"ENGEBRECHT, J, MER1, A YEAST GENE REQUIRED FOR CHROMOSOME-PAIRING AND GENETIC-RECOMBINATION, IS INDUCED IN MEIOSIS, MOLECULAR AND CELLULAR BIOLOGY 10: 2379 (1990).","journal-title":"MOLECULAR AND CELLULAR BIOLOGY"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90283-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/ng0892-341","volume":"1","year":"1992","unstructured":"GIDEON, A.K., NAT GENET 1: 341 (1992).","journal-title":"NAT GENET"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0076-6879(90)83011-W","volume":"183","year":"1990","unstructured":"GRIBSKOV, M, PROFILE ANALYSIS, METHODS IN ENZYMOLOGY 183: 146 (1990).","journal-title":"METHODS IN ENZYMOLOGY"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ng0193-36","volume":"3","year":"1993","unstructured":"HINDS, H.L., TISSUE SPECIFIC EXPRESSION OF FMR-1 PROVIDES EVIDENCE FOR A FUNCTIONAL-ROLE IN FRAGILE-X SYNDROME, NATURE GENETICS 3: 36 (1993).","journal-title":"NATURE GENETICS"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1128\/jvi.66.11.6322-6329.1992","volume":"66","year":"1992","unstructured":"KAO, C.C., BROME MOSAIC-VIRUS RNA REPLICATION PROTEIN-1A AND PROTEIN-2A FORM A COMPLEX INVITRO, JOURNAL OF VIROLOGY 66: 6322 (1992).","journal-title":"JOURNAL OF VIROLOGY"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1675488"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0092-8674(93)90265-R","volume":"73","year":"1993","unstructured":"MATTAJ, I.W., RNA RECOGNITION - 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