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The potent vasoconstrictor property of thromboxanes can be dissociated from its capacity to produce platelet aggregation. Furthermore, thromboxane formation is not an essential process in platelet aggregation. The observations indicate the remarkable structural specificity of both the synthetic enzymes, cyclooxygenase and thromboxane synthetase, as well as the vascular and platelet receptor sites.\n          <\/jats:p>","DOI":"10.1126\/science.945611","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:51:28Z","timestamp":1160063488000},"page":"163-165","source":"Crossref","is-referenced-by-count":323,"title":["Thromboxanes: Selective Biosynthesis and Distinct Biological Properties"],"prefix":"10.1126","volume":"193","author":[{"given":"Philip","family":"Needleman","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Surgery, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Minkes","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Surgery, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amiram","family":"Raz","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Surgery, Washington University Medical School, St. Louis, Missouri 63110"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"1","volume":"20","year":"1968","unstructured":"BERGSTROM, S, POSTAGLANDINS - A FAMILY OF BIOLOGICALLY ACTIVE LIPIDS, PHARMACOLOGICAL REVIEWS 20: 1 (1968).","journal-title":"PHARMACOLOGICAL REVIEWS"},{"key":"e_1_2_1_2_1","first-page":"344","volume":"56","year":"1976","unstructured":"BUNTING, S, BRIT J PHARMACOL 56: 344 (1976).","journal-title":"BRIT J PHARMACOL"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.2.345"},{"key":"e_1_2_1_4_1","first-page":"2994","volume":"72","year":"1975","unstructured":"HAMBERG, M, THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 2994 (1975).","journal-title":"PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"},{"key":"e_1_2_1_5_1","first-page":"1446","volume":"72","year":"1975","unstructured":"MALMSTEN, C, PROSTAGLANDIN ENDOPEROXIDES .8. 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