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It is possible to understand a large number of different behaviors of epimorphic fields as a straight-forward consequence of these two rules, and the model therefore provides a context in which to view many of the results of experimental embryology. Although we have confined our discussion to cockroach legs, the imaginal disks of Drosophila, and regenerating and developing amphibian limbs, the fact that the model can explain regulative behavior in such evolutionarily diverse animals suggests that it may have general applicability to epimorphic fields. The predictions which the model makes should make it possible to assess its applicability to other developing systems, and to investigate the cellular mechanisms involved.<\/jats:p>","DOI":"10.1126\/science.948762","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T15:51:28Z","timestamp":1160063488000},"page":"969-981","source":"Crossref","is-referenced-by-count":707,"title":["Pattern Regulation in Epimorphic Fields"],"prefix":"10.1126","volume":"193","author":[{"given":"Vernon","family":"French","sequence":"first","affiliation":[{"name":"National Institute for Medical Research, Mill Hill, London, N.W.7, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology and the Center for Pathobiology, University of California, Irvine 92717."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan V.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology and the Center for Pathobiology, University of California, Irvine 92717."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02152140","volume":"20","year":"1964","unstructured":"BARASA, A, ON REGULATIVE CAPACITY OF CHICK EMBRYO LIMB BUD, EXPERIENTIA 20: 443 (1964).","journal-title":"EXPERIENTIA"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00584822","volume":"166","year":"1971","unstructured":"BART, A, W ROUXS ARCH 166: 331 (1971).","journal-title":"W ROUXS ARCH"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ar.1091610411","volume":"161","year":"1968","unstructured":"BELLAIRS, A, ANATOMICAL RECORD 161: 489 (1968).","journal-title":"ANATOMICAL RECORD"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/BF00582218","volume":"136","year":"1937","unstructured":"BODENSTEIN, D, W ROUX ARCH ENTWMECH 136: 745 (1937).","journal-title":"W ROUX ARCH ENTWMECH"},{"key":"e_1_2_1_5_1","first-page":"185","volume":"28","year":"1972","unstructured":"BOHN, H, ORIGIN OF EPIDERMIS IN SUPERNUMERARY REGENERATES OF TRIPLE LEGS IN COCKROACHES (BLATTARIA), JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY 28: 185 (1972).","journal-title":"JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY"},{"key":"e_1_2_1_6_1","first-page":"557","volume":"31","year":"1974","unstructured":"BOHN, H, EXTENT AND PROPERTIES OF REGENERATION FIELD IN LARVAL LEGS OF COCKROACHES LEUCOPHAEA-MADERAE .1. 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