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Here, we identify the stretch-activated anion channel MSL10 as necessary for proper wound-induced electrical and Ca\n            <jats:sup>2+<\/jats:sup>\n            signaling. Wound gene induction, genetics, and Ca\n            <jats:sup>2+<\/jats:sup>\n            imaging indicate that MSL10 acts in the same pathway as the glutamate receptor\u2013like proteins (GLRs). Analogous to mammalian NMDA glutamate receptors, GLRs may serve as coincidence detectors gated by the combined requirement for ligand binding and membrane depolarization, here mediated by stretch activation of MSL10. This study provides a molecular genetic basis for a role of mechanical signal perception and the transmission of long-distance electrical and Ca\n            <jats:sup>2+<\/jats:sup>\n            signals in plants.\n          <\/jats:p>","DOI":"10.1126\/sciadv.abg4298","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T19:02:11Z","timestamp":1631127731000},"source":"Crossref","is-referenced-by-count":82,"title":["Interdependence of a mechanosensitive anion channel and glutamate receptors in distal wound signaling"],"prefix":"10.1126","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4771-7618","authenticated-orcid":true,"given":"Jacob","family":"Moe-Lange","sequence":"first","affiliation":[{"name":"Department of Biology, Stanford University, Stanford, CA 94305, USA."},{"name":"Institute for Molecular Physiology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."},{"name":"Department of Plant Biology, Carnegie Science, Stanford, CA 94305, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-2384","authenticated-orcid":true,"given":"Nicoline M.","family":"Gappel","sequence":"additional","affiliation":[{"name":"Institute for Molecular Physiology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}]},{"given":"Mackenzie","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, Carnegie Science, Stanford, CA 94305, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4332-369X","authenticated-orcid":true,"given":"Michael M.","family":"Wudick","sequence":"additional","affiliation":[{"name":"Institute for Molecular Physiology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-047X","authenticated-orcid":true,"given":"Cosima S. A.","family":"Sies","sequence":"additional","affiliation":[{"name":"Institute for Molecular Physiology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0735-1404","authenticated-orcid":true,"given":"Stephan N.","family":"Schott-Verdugo","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."},{"name":"Centro de Bioinform\u00e1tica y Simulaci\u00f3n Molecular (CBSM), Facultad de Ingenier\u00eda, Universidad de Talca, 2 Norte 685, CL-3460000 Talca, Chile."},{"name":"John von Neumann Institute for Computing (NIC), J\u00fclich Supercomputing Centre (JSC), Institute of Biological Information Processing (IBI-7: Structural Bioinformatics), and Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum J\u00fclich GmbH, Wilhelm-Johnen-Str., 52425 J\u00fclich, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-7342","authenticated-orcid":true,"given":"Michele","family":"Bonus","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}]},{"given":"Swastik","family":"Mishra","sequence":"additional","affiliation":[{"name":"Computational Cell Biology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2707-2771","authenticated-orcid":true,"given":"Thomas","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Institute for Molecular Physiology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8009-3635","authenticated-orcid":true,"given":"Margaret","family":"Bezrutczyk","sequence":"additional","affiliation":[{"name":"Institute for Molecular Physiology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-7636","authenticated-orcid":true,"given":"Debarati","family":"Basu","sequence":"additional","affiliation":[{"name":"NSF Center for Engineering Mechanobiology, Department of Biology, Washington University in St. Louis, Box 1137, One Brookings Drive, St. Louis, MO 63130, USA."}]},{"given":"Edward E.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Plant Molecular Biology, University of Lausanne, CH-1015 Lausanne, Switzerland."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8613-1447","authenticated-orcid":true,"given":"Holger","family":"Gohlke","sequence":"additional","affiliation":[{"name":"Institute for Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany."},{"name":"John von Neumann Institute for Computing (NIC), J\u00fclich Supercomputing Centre (JSC), Institute of Biological Information Processing (IBI-7: Structural Bioinformatics), and Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum J\u00fclich GmbH, Wilhelm-Johnen-Str., 52425 J\u00fclich, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-8602","authenticated-orcid":true,"given":"Andrey","family":"Malkovskiy","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, Carnegie Science, Stanford, CA 94305, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-065X","authenticated-orcid":true,"given":"Elizabeth S.","family":"Haswell","sequence":"additional","affiliation":[{"name":"NSF Center for Engineering Mechanobiology, Department of Biology, Washington University in St. Louis, Box 1137, One Brookings Drive, St. Louis, MO 63130, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3940-1621","authenticated-orcid":true,"given":"Martin J.","family":"Lercher","sequence":"additional","affiliation":[{"name":"Computational Cell 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