{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:34:44Z","timestamp":1774499684684,"version":"3.50.1"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2022,6,17]]},"abstract":"<jats:p>Traceless physical cues are desirable for remote control of the in situ production and real-time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic, magnetogenetic, or electrogenetic devices require sophisticated electronics, complex artificial intelligence\u2013assisted software, and external energy supplies for power and control. Here, we describe a self-sufficient subcutaneous push button\u2013controlled cellular implant powered simply by repeated gentle finger pressure exerted on the overlying skin. Pushing the button causes transient percutaneous deformation of the implant\u2019s embedded piezoelectric membrane, which produces sufficient low-voltage energy inside a semi-permeable platinum-coated cell chamber to mediate rapid release of a biopharmaceutical from engineered electro-sensitive human cells. Release is fine-tuned by varying the frequency and duration of finger-pressing stimulation. As proof of concept, we show that finger-pressure activation of the subcutaneous implant can restore normoglycemia in a mouse model of type 1 diabetes. Self-sufficient push-button devices may provide a new level of convenience for patients to control their cell-based therapies.<\/jats:p>","DOI":"10.1126\/sciadv.abm4389","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T17:53:55Z","timestamp":1655315635000},"source":"Crossref","is-referenced-by-count":47,"title":["Autonomous push button\u2013controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant"],"prefix":"10.1126","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8706-4597","authenticated-orcid":true,"given":"Haijie","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-3833","authenticated-orcid":true,"given":"Shuai","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering, ETH 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