{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:40:29Z","timestamp":1792521629073,"version":"4.5.0"},"reference-count":103,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"41","funder":[{"name":"The Voland Fund"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,9]]},"abstract":"<jats:p>\n                    Aldabra giant tortoises (\n                    <jats:italic toggle=\"yes\">Aldabrachelys gigantea<\/jats:italic>\n                    ) are exceptionally long-lived. We sequenced the genome and methylome of Jonathan, a 194-year-old Aldabra, to explore the molecular basis of his longevity. Relative to other giant tortoises (\n                    <jats:italic toggle=\"yes\">A. gigantea<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Chelonoidis abingdonii<\/jats:italic>\n                    ), Jonathan has unique gene variants in most aging pathways. Moreover, Jonathan has substantial DNA methylation and methylation entropy changes compared to four other Aldabras ranging in age from a 5-year-old juvenile to older adults. Notably, we found that lower-entropy regions in Jonathan\u2019s methylome were enriched for the promoters of genes involved in the mitochondrial electron transport chain, and RNA metabolism. This suggests that high-fidelity transcription of the genes in these pathways may be crucial for long-lived species. Our findings support a model for aging wherein the maintenance of low methylation entropy in gene promoters is coupled to efficient mitochondrial energy production, efficient RNA processing, and efficient genomic repair.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.adw8887","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:58:33Z","timestamp":1791395913000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic insights into extreme longevity in the world\u2019s oldest terrestrial animal, Jonathan"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-0295","authenticated-orcid":true,"given":"Benjamin","family":"Vaisvil","sequence":"first","affiliation":[{"name":"Kallel Foundation, Nashville, TN, USA."},{"name":"Igenbio, Inc., Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6057-5669","authenticated-orcid":true,"given":"Daniel P.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Igenbio, Inc., Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1565-4360","authenticated-orcid":true,"given":"Angela","family":"Jones","sequence":"additional","affiliation":[{"name":"VANTAGE, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Kapatral","sequence":"additional","affiliation":[{"name":"Igenbio, Inc., Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Ford","sequence":"additional","affiliation":[{"name":"Vanderbilt University, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison L.","family":"Taylor","sequence":"additional","affiliation":[{"name":"VANTAGE, Vanderbilt University Medical Center, Nashville, TN, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-8520","authenticated-orcid":true,"given":"Mathia","family":"Colwell","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8290-0903","authenticated-orcid":true,"given":"Jonathan","family":"Hollins","sequence":"additional","affiliation":[{"name":"Agriculture and Natural Resources Division, St. Helena Government, Jamestown, St. Helena."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Pascucci","sequence":"additional","affiliation":[{"name":"Florida Iguana &amp; 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