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However, the underlying molecular mechanisms around how NAD\n                    <jats:sup>+<\/jats:sup>\n                    enhances neuronal resilience, especially whether it has any effect on ASEs, have remained elusive. This study shows that NAD\n                    <jats:sup>+<\/jats:sup>\n                    augmentation corrects the ASEs of many genes via a key protein, EVA1C (epithelial V-like antigen 1 homolog C), which is involved in neuronal development and activities. EVA1C is reduced in the hippocampus in patients with AD compared to cognitively normal ones. NAD\n                    <jats:sup>+<\/jats:sup>\n                    -induced memory retention is partially dependent on EVA1C, as adeno-associated virus\u2013based\n                    <jats:italic toggle=\"yes\">Eva1c<\/jats:italic>\n                    knockdown in the hippocampal CA1 region annuls NAD\n                    <jats:sup>+<\/jats:sup>\n                    -induced memory improvement in pathological Tau\u2013bearing mice. We propose that NAD\n                    <jats:sup>+<\/jats:sup>\n                    reduces AD pathologies, at least partially, via amplification of the NAD\n                    <jats:sup>+<\/jats:sup>\n                    -\n                    <jats:italic toggle=\"yes\">EVA1C<\/jats:italic>\n                    splicing axis, pointing to a potential splice-switching therapy for AD.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.ady9811","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:58:33Z","timestamp":1762541913000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":4,"title":["NAD\n                    <sup>+<\/sup>\n                    reverses Alzheimer\u2019s neurological deficits via regulating differential alternative RNA splicing of\n                    <i>EVA1C<\/i>"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-3692","authenticated-orcid":true,"given":"Ruixue","family":"Ai","sequence":"first","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 L\u00f8renskog, Norway."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-0307","authenticated-orcid":true,"given":"Lipeng","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital, School of Medicine, Jian University, 510632 Guangzhou, China."},{"name":"Guangdong\u2013Hong Kong\u2013Macau Great Bay Area Geroscience Joint Laboratory, 510632 Guangzhou, China."},{"name":"Department of Systems Biomedical Sciences, School of Medicine, Jinan University, 510632 Guangzhou, China."}]},{"given":"Xurui","family":"Jin","sequence":"additional","affiliation":[{"name":"Mindrank AI Ltd., Hangzhou, China."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-4333","authenticated-orcid":true,"given":"Carlos","family":"Campos-Marques","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal."},{"name":"ICVS\/3B\u2019s - PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-7652","authenticated-orcid":true,"given":"Shi-qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 L\u00f8renskog, Norway."}]},{"given":"Junping","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 L\u00f8renskog, Norway."},{"name":"Department of Oncology, The First Affiliated Hospital, School of Medicine, Jian University, 510632 Guangzhou, China."},{"name":"Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, 510632 Guangzhou, China."}]},{"given":"Maria Jose","family":"Lagartos-Donate","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 L\u00f8renskog, Norway."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-8308","authenticated-orcid":true,"given":"Shu-Qin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 L\u00f8renskog, Norway."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5056-1629","authenticated-orcid":true,"given":"Beatriz","family":"Barros-Santos","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal."},{"name":"ICVS\/3B\u2019s - PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1364-6404","authenticated-orcid":true,"given":"Rita","family":"N\u00f3brega-Martins","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal."},{"name":"ICVS\/3B\u2019s - PT Government Associate Laboratory, Braga\/Guimar\u00e3es, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0183-1045","authenticated-orcid":true,"given":"Filippos","family":"Katsaitis","sequence":"additional","affiliation":[{"name":"Laboratory of Brain Exosomes and Pathology \u2013 ExoBrain, Institute of Biosciences and Applications, National Center for Scientific Research \u201cDemokritos,\u201d T. 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