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Adelson Medical Research Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:p>\n                    Injured axons synthesize the RNA Binding Protein KHSRP that promotes mRNA decay and slows nerve regeneration. Axotomy-induced increase in axoplasmic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    activates axonal\n                    <jats:italic toggle=\"yes\">Khsrp<\/jats:italic>\n                    translation, and while axonal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    returns to pre-injury levels within 16 hours post-axotomy, axonal KHSRP remains elevated. Alternating translation of\n                    <jats:italic toggle=\"yes\">Reg3a<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Khsrp<\/jats:italic>\n                    sustains KHSRP levels in regenerating axons. Axonal\n                    <jats:italic toggle=\"yes\">Reg3a<\/jats:italic>\n                    mRNA and protein increase proximal to the injury site days after sciatic nerve crush. REG3A stimulates ER Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release in axons to activate PERK, increase eIF2\u03b1 phosphorylation, and increase\n                    <jats:italic toggle=\"yes\">Khsrp<\/jats:italic>\n                    translation. Axoplasmic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    slowly oscillates in growth cones of cultured neurons and\n                    <jats:italic toggle=\"yes\">Reg3a<\/jats:italic>\n                    depletion attenuates growth cone Ca\n                    <jats:sup>2+<\/jats:sup>\n                    oscillations, decreases KHSRP synthesis and reduces axonal retractive events in cultured neurons, and accelerates peripheral nerve regeneration in vivo. Thus, REG3A regulation of axonal KHSRP synthesis provides a signaling loop that decelerates axon growth through localized mRNA translation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aed0049","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:59:39Z","timestamp":1787767179000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-1244","authenticated-orcid":true,"given":"Courtney N.","family":"Buchanan","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of South Carolina; Columbia, SC 29204 USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6778-4821","authenticated-orcid":true,"given":"Jinyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of South Carolina; 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