{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:25:15Z","timestamp":1790886315134,"version":"4.1.0"},"reference-count":68,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"40","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG075775"],"award-info":[{"award-number":["R01AG075775"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG083799"],"award-info":[{"award-number":["R01AG083799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2P01AG019724"],"award-info":[{"award-number":["2P01AG019724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG075775"],"award-info":[{"award-number":["R01AG075775"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG083799"],"award-info":[{"award-number":["R01AG083799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2P01AG019724"],"award-info":[{"award-number":["2P01AG019724"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG057234"],"award-info":[{"award-number":["R01AG057234"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG075775"],"award-info":[{"award-number":["R01AG075775"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG21051"],"award-info":[{"award-number":["R01AG21051"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG083799"],"award-info":[{"award-number":["R01AG083799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1D43TW012455-01A1"],"award-info":[{"award-number":["1D43TW012455-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG-20-725707"],"award-info":[{"award-number":["SG-20-725707"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ALZ-RWD-26-1466627"],"award-info":[{"award-number":["ALZ-RWD-26-1466627"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG-20-725707"],"award-info":[{"award-number":["SG-20-725707"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARGD-24-1310017"],"award-info":[{"award-number":["AARGD-24-1310017"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ANID\/FOVI240065"],"award-info":[{"award-number":["ANID\/FOVI240065"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028163","name":"EQuity Social Venture","doi-asserted-by":"publisher","award":["DOCTORADO BECAS CHILE\/2022"],"award-info":[{"award-number":["DOCTORADO BECAS CHILE\/2022"]}],"id":[{"id":"10.13039\/100028163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["227012\/Z\/23\/Z"],"award-info":[{"award-number":["227012\/Z\/23\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AG082056-01A1"],"award-info":[{"award-number":["1R01AG082056-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GBHI ALZ UK-23-971135"],"award-info":[{"award-number":["GBHI ALZ UK-23-971135"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["335293\/Z\/25\/Z"],"award-info":[{"award-number":["335293\/Z\/25\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["ReDLat2"],"award-info":[{"award-number":["ReDLat2"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG-20-725707"],"award-info":[{"award-number":["SG-20-725707"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016608","name":"Rainwater Charitable Foundation","doi-asserted-by":"publisher","award":["The Bluefield project to cure FTD"],"award-info":[{"award-number":["The Bluefield project to cure FTD"]}],"id":[{"id":"10.13039\/100016608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015442","name":"Global Brain Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG057234"],"award-info":[{"award-number":["R01AG057234"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016608","name":"Rainwater Charitable Foundation","doi-asserted-by":"publisher","award":["Tau Consortium"],"award-info":[{"award-number":["Tau Consortium"]}],"id":[{"id":"10.13039\/100016608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015442","name":"Global Brain Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015442","name":"Global Brain Health Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015442","name":"Global Brain Health Institute","doi-asserted-by":"publisher","award":["GBHI ALZ UK-23-971135"],"award-info":[{"award-number":["GBHI ALZ UK-23-971135"]}],"id":[{"id":"10.13039\/100015442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008069","name":"University of California, San Francisco","doi-asserted-by":"publisher","award":["P0544014"],"award-info":[{"award-number":["P0544014"]}],"id":[{"id":"10.13039\/100008069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG057234"],"award-info":[{"award-number":["R01AG057234"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANID","award":["1250317, 1250091"],"award-info":[{"award-number":["1250317, 1250091"]}],"id":[{"id":"https:\/\/ror.org\/05btm5233","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["01-PICTE-2022-05-00103"],"award-info":[{"award-number":["01-PICTE-2022-05-00103"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["15150012"],"award-info":[{"award-number":["15150012"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ANID\/FONDECYT","award":["1231839"],"award-info":[{"award-number":["1231839"]}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21210855"],"award-info":[{"award-number":["21210855"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1210622, 1250091"],"award-info":[{"award-number":["1210622, 1250091"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["NAM22I0007"],"award-info":[{"award-number":["NAM22I0007"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["13240170"],"award-info":[{"award-number":["13240170"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["3240042"],"award-info":[{"award-number":["3240042"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["13240170"],"award-info":[{"award-number":["13240170"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21250152"],"award-info":[{"award-number":["21250152"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006280","name":"Ministerio de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["RYC2022-035514-I"],"award-info":[{"award-number":["RYC2022-035514-I"]}],"id":[{"id":"10.13039\/501100006280","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIDA","award":["75N95022C00031"],"award-info":[{"award-number":["75N95022C00031"]}]},{"DOI":"10.13039\/100028163","name":"EQuity Social Venture","doi-asserted-by":"publisher","award":["R56AG069118-01, SG-21-715176-LATAM FIN- GERS, 24AARG-D-1246942"],"award-info":[{"award-number":["R56AG069118-01, SG-21-715176-LATAM FIN- GERS, 24AARG-D-1246942"]}],"id":[{"id":"10.13039\/100028163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028163","name":"EQuity Social Venture","doi-asserted-by":"publisher","award":["SG-21-715176-LATAM FIN"],"award-info":[{"award-number":["SG-21-715176-LATAM FIN"]}],"id":[{"id":"10.13039\/100028163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028163","name":"EQuity Social Venture","doi-asserted-by":"publisher","award":["24AARG-D-1246942"],"award-info":[{"award-number":["24AARG-D-1246942"]}],"id":[{"id":"10.13039\/100028163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028163","name":"EQuity Social Venture","doi-asserted-by":"publisher","award":["GBHI ALZ UK-25-1289623"],"award-info":[{"award-number":["GBHI ALZ UK-25-1289623"]}],"id":[{"id":"10.13039\/100028163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028163","name":"EQuity Social Venture","doi-asserted-by":"publisher","award":["NIH D43 F"],"award-info":[{"award-number":["NIH D43 F"]}],"id":[{"id":"10.13039\/100028163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028163","name":"EQuity Social Venture","doi-asserted-by":"publisher","award":["R01AG082056"],"award-info":[{"award-number":["R01AG082056"]}],"id":[{"id":"10.13039\/100028163","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["ANID\/PIA\/ANILLOS ACT210096"],"award-info":[{"award-number":["ANID\/PIA\/ANILLOS ACT210096"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DISCeRN","award":["RN 2025"],"award-info":[{"award-number":["RN 2025"]}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDEF ID20I10152"],"award-info":[{"award-number":["FONDEF ID20I10152"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["ANID\/FONDAP 15150012"],"award-info":[{"award-number":["ANID\/FONDAP 15150012"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100028897","name":"Wellcome Leap","doi-asserted-by":"publisher","award":["CARE-2025-0883490149"],"award-info":[{"award-number":["CARE-2025-0883490149"]}],"id":[{"id":"10.13039\/100028897","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ClicBrain","award":["Horizon ID: 101236426; DOI 10.3030\/101236426, Marie Sk\u0142odowska-Curie Actions - MSCA"],"award-info":[{"award-number":["Horizon ID: 101236426; DOI 10.3030\/101236426, Marie Sk\u0142odowska-Curie Actions - MSCA"]}]},{"name":"Davos Alzheimer's Collaborative"},{"name":"National Institutes of Aging","award":["R01 AG075775"],"award-info":[{"award-number":["R01 AG075775"]}]},{"name":"National Institutes of Aging","award":["R01 AG21051"],"award-info":[{"award-number":["R01 AG21051"]}]},{"name":"National Institutes of Aging","award":["R01 AG083799"],"award-info":[{"award-number":["R01 AG083799"]}]},{"name":"National Institutes of Aging","award":["CARDS-NIH"],"award-info":[{"award-number":["CARDS-NIH"]}]},{"name":"ANID\/FONDECYT","award":["1250091 and 1210176 and 1220995"],"award-info":[{"award-number":["1250091 and 1210176 and 1220995"]}]},{"name":"Bluefield Project to Cure Frontotemporal Dementia"},{"name":"ANID\/PIA\/ANILLOS","award":["ACT210096"],"award-info":[{"award-number":["ACT210096"]}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Discovery Award GRACE-Epi","award":["326117\/Z\/25\/Z"],"award-info":[{"award-number":["326117\/Z\/25\/Z"]}]},{"name":"NIH-NIDA","award":["75N95022C00031"],"award-info":[{"award-number":["75N95022C00031"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:p>Biological aging clocks offer estimations of aging and dementia, yet scalability is limited. We introduce a large-scale, cross-national speech clock derived from 2928 individuals across five Latin American countries, spanning healthy controls (HCs), mild cognitive impairment (MCI), Alzheimer\u2019s disease (AD), and non-language\/language-dominant frontotemporal dementia (nldFTD\/ldFTD). Multimodal acoustic and linguistic features were trained with supervised models to estimate chronological age, generating speech age gaps (SAGs) as cross-sectional markers of deviations from chronological age, with positive values interpreted as relatively older-appearing speech profiles. SAGs differentiated diagnostic groups (HCs\u00a0&lt;\u00a0patient groups, with AD &lt; nldFTD &lt; ldFTD). This pattern was associated with clinical\/cognitive domains. SAGs correlated with phosphorylated tau (p-Tau217) in AD and social exposome in HCs and AD. Brain clocks (structural\/functional\/combined) were associated with SAG in AD, nldFTD, and ldFTD. Epigenetic age correlated with SAGs in HCs and AD across Hannum, Retroclock, and OMICmAge, whereas ldFTD associations were limited to Retroclock and OMICmAge. These results indicate that SAGs capture cross-sectional multilevel aging-related variation and may offer a scalable, culturally adaptable, low-cost biomarker candidate for research in underrepresented global settings.<\/jats:p>","DOI":"10.1126\/sciadv.aef9864","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:26Z","timestamp":1790791106000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Speech clocks decode dementia phenotypes, social exposome, and biological aging"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-6059","authenticated-orcid":true,"given":"Hernan","family":"Hernandez","sequence":"first","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizeth Katherine","family":"Pedraza","sequence":"additional","affiliation":[{"name":"Laboratorio de Bases Biol\u00f3gicas del Comportamiento, Facultad de Ciencias del Comportamiento, Universidad de La Sabana, Ch\u00eda, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9422-3579","authenticated-orcid":true,"given":"Hernando","family":"Santamaria-Garcia","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana (PhD Program in Neuroscience), Bogot\u00e1, San Ignacio, Colombia."},{"name":"Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogot\u00e1, San Ignacio, Colombia."},{"name":"Universidad Nacional de Colombia, Bogot\u00e1, Colombia."},{"name":"Fundaci\u00f3n Santa Fe de Bogot\u00e1, Departamento de Salud Mental, Bogot\u00e1, Colombia."},{"name":"Universidad de los Andes, Bogot\u00e1, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-8325","authenticated-orcid":true,"given":"Sebastian","family":"Moguilner","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-6824","authenticated-orcid":true,"given":"Agustina","family":"Legaz","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-6400","authenticated-orcid":true,"given":"Pavel","family":"Prado","sequence":"additional","affiliation":[{"name":"Escuela de Fonoaudiolog\u00eda, Facultad de Ciencias de la Rehabilitaci\u00f3n y Calidad de Vida, Universidad San Sebasti\u00e1n, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-0171","authenticated-orcid":true,"given":"Jhosmary","family":"Cuadros","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Grupo de Bioingenier\u00eda, Decanato de Investigaci\u00f3n, Universidad Nacional Experimental del T\u00e1chira, San Crist\u00f3bal 5001, Venezuela."},{"name":"Advanced Center for Electrical and Electronic Engineering, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso 2390123, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-2187","authenticated-orcid":true,"given":"Luc\u00eda","family":"Amoruso","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Basque Center on Cognition, Brain and Language (BCBL), San Sebastian, Spain."},{"name":"Ikerbasque, Basque Foundation for Science, Bilbao, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liset","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Facultad de Ingenier\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0472-8472","authenticated-orcid":true,"given":"Dami\u00e1n","family":"Dellavale","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Centro At\u00f3mico Bariloche, San Carlos de Bariloche, R\u00edo Negro, Argentina."},{"name":"Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3192-5070","authenticated-orcid":true,"given":"Juan Pablo","family":"Espinoza\u2013Puelles","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile."},{"name":"IRyS Group, Physical Education School, Pontificia Universidad Cat\u00f3lica de Valpara\u00edso, Valpara\u00edso, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-2964","authenticated-orcid":true,"given":"Javier Palma","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso, Valpara\u00edso, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-920X","authenticated-orcid":true,"given":"Cecilia","family":"Jarne","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina."},{"name":"Universidad Nacional de Quilmes, Buenos Aires, Argentina."},{"name":"Aarhus Universitetshospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0037-2042","authenticated-orcid":true,"given":"Fabio","family":"Mattiussi","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Universitat Pompeu Fabra, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Caccia","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Sosa","family":"Welford","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0334-0918","authenticated-orcid":true,"given":"Nicol\u00e1s","family":"Pelella","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6919-7567","authenticated-orcid":true,"given":"Jerem\u00edas","family":"Inchauspe","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9455-2214","authenticated-orcid":true,"given":"Franco J.","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz, Buenos Aires, Argentina."},{"name":"Facultad de Ingenier\u00eda, Universidad de Buenos Aires, Col\u00f3n, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-8944","authenticated-orcid":true,"given":"Gonzalo","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz, Buenos Aires, Argentina."},{"name":"Facultad de Ingenier\u00eda, Universidad de Buenos Aires, Col\u00f3n, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5909-7740","authenticated-orcid":true,"given":"Marcelo Adri\u00e1n","family":"Maito","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8941-2188","authenticated-orcid":true,"given":"Guido","family":"Rocatti","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Godoy","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Migeot","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-7750","authenticated-orcid":true,"given":"Paulina","family":"Orellana","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4373-5587","authenticated-orcid":true,"given":"Ariel","family":"Caviedes","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bruno","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Godoy Cruz, Buenos Aires, Argentina."},{"name":"Instituto de Ciencias Biom\u00e9dicas (ICBM), Universidad Cat\u00f3lica de Cuyo, San Juan, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-9253","authenticated-orcid":true,"given":"Leonel","family":"Takada","sequence":"additional","affiliation":[{"name":"Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Slachevsky","sequence":"additional","affiliation":[{"name":"Centro Gerociencias, Salud Mental y Metabolismo (GERO), Santiago, Chile."},{"name":"Laboratorio de Neuropsicolog\u00eda y Neurociencias Cl\u00ednicas (LANNEC), N\u00facleo Interdisciplinario de Fisiolog\u00eda, Biof\u00edsica y Fisiopatolog\u00eda-ICBM, Departamento de Ciencias Neurol\u00f3gicas Oriente y Neurociencias, Facultad de Medicina, Universidad de Chile, Avenida Salvador 486, Providencia, Santiago, Chile."},{"name":"Centro de Memoria y Neuropsiquiatr\u00eda (CMYN), Servicio de Neurolog\u00eda, Hospital del Salvador y Facultad de Medicina, Universidad de Chile, Santiago, Chile."},{"name":"Departamento de Neurolog\u00eda y Psiquiatr\u00eda, Cl\u00ednica Alemana-Universidad del Desarrollo, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0964-426X","authenticated-orcid":true,"given":"Maria I","family":"Behrens","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda y Psiquiatr\u00eda, Cl\u00ednica Alemana-Universidad del Desarrollo, Santiago, Chile."},{"name":"Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico Universidad de Chile, Santiago, Chile."},{"name":"Departamento de Neurolog\u00eda y Neurocirug\u00eda, Hospital Cl\u00ednico Universidad de Chile, Santiago, Chile."},{"name":"Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Bruna","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cl\u00ednica Avanzada (CICA), Hospital Cl\u00ednico Universidad de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-536X","authenticated-orcid":true,"given":"David","family":"Aguillon","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-4981","authenticated-orcid":true,"given":"Lina","family":"Zapata","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA."},{"name":"Fundacion Valle del Lili, Cali, Colombia."},{"name":"Universidad Icesi, Cali, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-5508","authenticated-orcid":true,"given":"Jose Alberto","family":"Avila-Funes","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Ensenanza, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubir\u00e1n, DF, Mexico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-3272","authenticated-orcid":true,"given":"Nilton","family":"Custodio","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n de Deterioro Cognitivo y Prevenci\u00f3n de Demencia, Instituto Peruano de Neurociencias, Lince, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-4220","authenticated-orcid":true,"given":"Bruce","family":"Miller","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA."},{"name":"Edward and Pearl Fein Memory and Aging Center, University of California, San Francisco (UCSF), San Francisco, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-7782","authenticated-orcid":true,"given":"Maria Luisa","family":"Gorno-Tempini","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA."},{"name":"Trinity College Dublin, The University of Dublin, Dublin, Ireland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7467-8365","authenticated-orcid":true,"given":"Stefanie Pina","family":"Escudero","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA."},{"name":"Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-7157","authenticated-orcid":true,"given":"Pablo","family":"Reyes","sequence":"additional","affiliation":[{"name":"Departamento de Psiquiatr\u00eda y Salud Mental, Facultad de Medicina, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia."},{"name":"Oficina de Investigaciones, Hospital Universitario San Ignacio, Bogot\u00e1, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-3132","authenticated-orcid":true,"given":"Kun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Massachusetts, USA."},{"name":"Division of Sleep Medicine, Harvard Medical School, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira Okada","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA."},{"name":"Department of Neurology, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9428-2410","authenticated-orcid":true,"given":"Carlos","family":"Coronel-Oliveros","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Trinity College Dublin, The University of Dublin, Dublin, Ireland."},{"name":"Departamento de Biolog\u00eda, Facultad de Ciencias, Universidad de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-8657","authenticated-orcid":true,"given":"Josephine","family":"Cruzat","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-7753","authenticated-orcid":true,"given":"Juan Felipe","family":"Cardona","sequence":"additional","affiliation":[{"name":"Department of Developmental Sciences, Cognition and Neuroscience, Faculty of Psychology, Universidad del Valle, Cali, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Corley","sequence":"additional","affiliation":[{"name":"Rose Stein Institute for Research on Aging and Center for Healthy Aging, UCSD, La Jolla (San Diego), USA."},{"name":"University of California San Diego Department of Medicine, Division of Geriatrics, Gerontology, and Palliative Care, UCSD, La Jolla (San Diego), USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene B.","family":"Meier","sequence":"additional","affiliation":[{"name":"Davos Alzheimer\u2019s Collaborative, Wayne PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav A.","family":"Narayan","sequence":"additional","affiliation":[{"name":"Davos Alzheimer\u2019s Collaborative, Wayne PA, USA."},{"name":"Mental Health Goals Program, Office of Life Sciences UK Visiting Professor, Kings College, London, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-9993","authenticated-orcid":true,"given":"Enzo","family":"Tagliazucchi","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"University of Buenos Aires, Buenos Aires, Argentina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-1709","authenticated-orcid":true,"given":"Sandra","family":"Baez","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute (GBHI), Trinity College Dublin (TCD), Dublin, Ireland."},{"name":"Departamento de Psicolog\u00eda, Universidad de los Andes, Bogot\u00e1, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-8366","authenticated-orcid":true,"given":"Claudia","family":"Duran-Aniotz","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6936-0114","authenticated-orcid":true,"given":"Adolfo M.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA."},{"name":"Departamento de Ling\u00fc\u00edstica y Literatura, Facultad de Humanidades, Universidad de Santiago de Chile, Santiago, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-5101","authenticated-orcid":true,"given":"Agustin","family":"Ibanez","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago de Chile, Chile."},{"name":"Cognitive Neuroscience Center, Departamento de Ciencias de la Vida y del Comportamiento, Universidad de San Andr\u00e9s, Buenos Aires, Argentina."},{"name":"Trinity College Dublin, The University of Dublin, Dublin, Ireland."},{"name":"Department of Biophysics, School of Medicine, Istanbul Medipol University, 34815 Istanbul, T\u00fcrkiye."},{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation, 08005 Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03808-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-67448-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03846-w"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00928-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03209-x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64173-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-026-04302-z"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03999-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02296-6"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102552"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70558"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59964-z"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-01000-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14295"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63277-6"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105697"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02495-1"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ac87d0"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad253"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004236"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44159-026-00553-2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-024-00630-4"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13472"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08359-z"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03856-8"},{"key":"e_1_3_2_27_2","first-page":"96","article-title":"Toolkit to Examine Lifelike Language v.2.0: Optimizing speech biomarkers of neurodegeneration","volume":"54","author":"Garc\u00eda A. M.","year":"2025","unstructured":"A. M. Garc\u00eda, F. J. Ferrante, G. P\u00e9rez, J. Ponferrada, A. S. Welford, N. Pelella, M. Caccia, L. M. L. Belloli, C. Calcaterra, C. G. Santib\u00e1\u00f1ez, R. Echegoyen, M. J. Cerrutti, F. Johann, E. Hesse, F. Carrillo, Toolkit to Examine Lifelike Language v.2.0: Optimizing speech biomarkers of neurodegeneration. Dement. Geriatr. Cogn. Disord. 54, 96\u2013108 (2025).","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-023-02240-z"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.04.016"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.631722"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03605-x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00520-w"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00361-6"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44220-025-00502-7"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-024-00802-4"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805234105"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.71365"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-026-02141-x"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02448-8"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.2196\/74200"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117522"},{"key":"e_1_3_2_44_2","first-page":"e12450","article-title":"Representativeness of samples enrolled in Alzheimer\u2019s disease research centers","volume":"15","author":"Renter\u00eda M. A.","year":"2023","unstructured":"M. A. Renter\u00eda, T. M. Mobley, N. D. Evangelista, L. D. Medina, K. D. Deters, J. T. Fox-Fuller, L. R. Minto, J. Avila-Rieger, B. M. Bettcher, Representativeness of samples enrolled in Alzheimer\u2019s disease research centers. Alzheimers Dement. 15, e12450 (2023).","journal-title":"Alzheimers Dement."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1142642"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.624137"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcomp.2021.780169"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-01061-3"},{"key":"e_1_3_2_49_2","first-page":"100387","article-title":"Classification of Alzheimer\u2019s disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study","volume":"17","author":"Maito M. A.","year":"2023","unstructured":"M. A. Maito, H. Santamar\u00eda-Garc\u00eda, S. Moguilner, K. L. Possin, M. E. Godoy, J. A. Avila-Funes, M. I. Behrens, I. L. Brusco, M. A. Bruno, J. F. Cardona, N. Custodio, A. M. Garc\u00eda, S. Javandel, F. Lopera, D. L. Matallana, B. Miller, M. O. de Oliveira, S. D. Pina-Escudero, A. Slachevsky, A. L. S. Ortiz, L. T. Takada, E. Tagliazuchi, V. Valcour, J. S. Yokoyama, A. Iba\u00f1ez, Classification of Alzheimer\u2019s disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study. Lancet Reg. Health Am. 17, 100387 (2023).","journal-title":"Lancet Reg. Health Am."},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0176-z"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_3_2_55_2","first-page":"3146","article-title":"LightGBM: A highly efficient gradient boosting decision tree","volume":"30","author":"Ke G.","year":"2017","unstructured":"G. Ke, Q. Meng, T. Finley, T. Wang, W. Chen, W. Ma, Q. Ye, T. Liu, LightGBM: A highly efficient gradient boosting decision tree. Adv. Neural Inf. Process. Syst. 30, 3146\u20133154 (2017).","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.100.032305"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14085"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25533"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-77914-5"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-86"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.80"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0673-2"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37729-w"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-025-00265-6"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2012.00111"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31384-3"},{"key":"e_1_3_2_68_2","first-page":"36","article-title":"SMOGN: A pre-processing approach for imbalanced regression","volume":"74","author":"Branco P.","year":"2017","unstructured":"P. Branco, L. Torgo, R. P. Ribeiro, SMOGN: A pre-processing approach for imbalanced regression. Proc. Mach. Learn. Res. 74, 36\u201350 (2017).","journal-title":"Proc. Mach. Learn. Res."},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.017"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aef9864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:59:27Z","timestamp":1790791167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aef9864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":68,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2026,10,2]]}},"alternative-id":["10.1126\/sciadv.aef9864"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aef9864","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]},"assertion":[{"value":"2026-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaef9864"}}