{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:40:56Z","timestamp":1767843656221,"version":"3.49.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5921","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2009,3,20]]},"abstract":"<jats:p>\n            DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, which suggests that this modification must be tightly controlled. However, accidental changes in DNA methylation can be transmitted through mitosis (as in cancer) or meiosis, leading to epiallelic variation. We demonstrated the existence of an efficient mechanism that protects against transgenerational loss of DNA methylation in\n            <jats:italic>Arabidopsis<\/jats:italic>\n            . Remethylation is specific to the subset of heavily methylated repeats that are targeted by the RNA interference (RNAi) machinery. This process does not spread into flanking regions, is usually progressive over several generations, and faithfully restores wild-type methylation over target sequences in an RNAi-dependent manner. Our findings suggest an important role for RNAi in protecting genomes against long-term epigenetic defects.\n          <\/jats:p>","DOI":"10.1126\/science.1165313","type":"journal-article","created":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T02:10:48Z","timestamp":1233281448000},"page":"1600-1604","source":"Crossref","is-referenced-by-count":316,"title":["A Role for RNAi in the Selective Correction of DNA Methylation Defects"],"prefix":"10.1126","volume":"323","author":[{"given":"Felipe Karam","family":"Teixeira","sequence":"first","affiliation":[{"name":"Unite\u0301 de Recherche en Ge\u0301nomique Ve\u0301ge\u0301tale, CNRS UMR 8114, Institut National de la Recherche Argonomique UMR 1165, Universite\u0301 d'Evry Val d'Essonne, 91057 Evry Cedex, France."},{"name":"CNRS UMR 8186, De\u0301partement de Biologie, Ecole Normale Supe\u0301rieure, 75230 Paris Cedex 05, France."},{"name":"Institut de Biologie Mole\u0301culaire des Plantes, CNRS Unite\u0301 Propre de Recherche 2357, 67084 Strasbourg Cedex, France."},{"name":"CNRS UMR 218, Institut Curie, 75248 Paris Cedex 05, France."},{"name":"Ge\u0301noscope, Commissariat a\u0300 L'Energie Atomique\u2013Institut de Ge\u0301nomique, 91057 Evry Cedex, France."}]},{"given":"Fabiana","family":"Heredia","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Recherche en Ge\u0301nomique Ve\u0301ge\u0301tale, CNRS UMR 8114, Institut National de la Recherche Argonomique UMR 1165, Universite\u0301 d'Evry Val d'Essonne, 91057 Evry Cedex, France."},{"name":"CNRS UMR 8186, De\u0301partement de Biologie, Ecole Normale Supe\u0301rieure, 75230 Paris Cedex 05, France."},{"name":"Institut de Biologie Mole\u0301culaire des Plantes, CNRS Unite\u0301 Propre de Recherche 2357, 67084 Strasbourg Cedex, France."},{"name":"CNRS UMR 218, Institut Curie, 75248 Paris Cedex 05, France."},{"name":"Ge\u0301noscope, Commissariat a\u0300 L'Energie Atomique\u2013Institut de Ge\u0301nomique, 91057 Evry Cedex, 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Lippman, B. May, C. Yordan, T. Singer, R. Martienssen, PLoS Biol.1, 420 (2003).","journal-title":"PLoS Biol."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611456104"},{"key":"e_1_3_2_23_2","first-page":"479","volume":"5","year":"2007","unstructured":"K. D. Kasschauet al., PLoS Biol.5, 479 (2007).","journal-title":"PLoS Biol."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1804"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601150"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2467"},{"key":"e_1_3_2_27_2","unstructured":"We thank P. Audigier for plant care A. Bulski for DNA samples R. Martienssen for sharing unpublished observations and E. Heard for critical reading of the manuscript. F.K.T. was supported by a Ph.D. studentship (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior Brazil) and F.H. and C.C. by postdoctoral fellowships [Network of Excellence (NoE) \u201cThe Epigenome\u201d and Fondation pour la Recherche M\u00e9dicale respectively]. Grant support was from Agence Nationale de la Recherche\u2013Programme Blanc (PolIV) NoE \u201cThe Epigenome \u201d G\u00e9noplante (EPIVAR) G\u00e9noscope and CNRS (PIME). The Gene Expression Omnibus accession number for sRNA sequences is GSE13419."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1165313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:31:21Z","timestamp":1704879081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1165313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,20]]},"references-count":26,"journal-issue":{"issue":"5921","published-print":{"date-parts":[[2009,3,20]]}},"alternative-id":["10.1126\/science.1165313"],"URL":"https:\/\/doi.org\/10.1126\/science.1165313","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,20]]}}}