{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:48:31Z","timestamp":1776782911683,"version":"3.51.2"},"reference-count":24,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5984","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2010,6,11]]},"abstract":"<jats:title>Too Much of a Good Thing<\/jats:title>\n                  <jats:p>\n                    In peripheral nerves, the insulating myelin sheath speeds up electrical conductivity by allowing impulses to skip down the axon from node to node. Axons signal using neuregulin to get the Schwann cells to begin their wrap-around insulation project. But when is enough myelin too much?\n                    <jats:bold>\n                      Cotter\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"1415\" related-article-type=\"in-this-issue\" vol=\"328\" xlink:href=\"10.1126\/science.1187735\">1415<\/jats:related-article>\n                    , published online 6 May) have now found the signal that stops further rounds of myelin insulation. In developing mice, the proteins Dlg1 (mammalian disc large 1) and PTEN (phosphatase and tensin homolog) were involved in calling a halt to insulation during early development. The balance between not enough and too much myelin insulation is controlled by opposing signals, which together optimize both the myelination and the velocity of nerve conduction.\n                  <\/jats:p>","DOI":"10.1126\/science.1187735","type":"journal-article","created":{"date-parts":[[2010,5,6]],"date-time":"2010-05-06T22:18:27Z","timestamp":1273184307000},"page":"1415-1418","source":"Crossref","is-referenced-by-count":155,"title":["Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination"],"prefix":"10.1126","volume":"328","author":[{"given":"Laurent","family":"Cotter","sequence":"first","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]},{"given":"Murat","family":"\u00d6z\u00e7elik","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]},{"given":"Claire","family":"Jacob","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]},{"given":"Jorge A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]},{"given":"Veronica","family":"Locher","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]},{"given":"Reto","family":"Baumann","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]},{"given":"Jo\u00e3o B.","family":"Relvas","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."},{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal."}]},{"given":"Ueli","family":"Suter","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]},{"given":"Nicolas","family":"Tricaud","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Department of Biology, Eidgen\u00f6ssische Technische Hochschule (ETH) Z\u00fcrich, CH-8093 Z\u00fcrich, Switzerland."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880030207"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00203-X"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095862"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.017"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(90)90018-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi400"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1196"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2493-05.2005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2741\/3182"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1423-09.2009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.035"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1134069"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5185-09.2010"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.08.008"},{"key":"e_1_3_2_17_2","first-page":"35","article-title":"Threonine phosphorylation of the MMAC1\/PTEN PDZ binding domain both inhibits and stimulates PDZ binding","volume":"60","author":"Adey N. 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