{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:45:37Z","timestamp":1770277537169,"version":"3.49.0"},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6054","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2011,10,21]]},"abstract":"<jats:p>A two-segment HIV epitope grafted into a scaffold protein maintains high affinity for a broadly neutralizing antibody.<\/jats:p>","DOI":"10.1126\/science.1209368","type":"journal-article","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T18:47:20Z","timestamp":1319136440000},"page":"373-376","source":"Crossref","is-referenced-by-count":210,"title":["Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold"],"prefix":"10.1126","volume":"334","author":[{"given":"Mihai L.","family":"Azoitei","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."}]},{"given":"Bruno E.","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."},{"name":"Ph.D. Program in Computational Biology, Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal."}]},{"given":"Yih-En Andrew","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."}]},{"given":"Chris","family":"Carrico","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."},{"name":"Divison of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA."}]},{"given":"Oleksandr","family":"Kalyuzhniy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA."}]},{"given":"Alexandria","family":"Schroeter","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."}]},{"given":"Po-Ssu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."}]},{"given":"Jason S.","family":"McLellan","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA."}]},{"given":"Peter D.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA."}]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."},{"name":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA."}]},{"given":"Roland K.","family":"Strong","sequence":"additional","affiliation":[{"name":"Divison of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA."}]},{"given":"William R.","family":"Schief","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Washington, Seattle, WA 98195, USA."},{"name":"IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA."},{"name":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01556"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190239"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1202617"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.06.010"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004728107"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.251"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja034508o"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1733910100"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt768"},{"key":"e_1_3_2_11_2","first-page":"11979","article-title":"Changing the structural context of a functional beta-hairpin. Synthesis and characterization of a chimera containing the curaremimetic loop of a snake toxin in the scorpion alpha\/beta scaffold","volume":"271","author":"Drakopoulou E.","year":"1996","unstructured":"Drakopoulou E., et al.., Changing the structural context of a functional beta-hairpin. Synthesis and characterization of a chimera containing the curaremimetic loop of a snake toxin in the scorpion alpha\/beta scaffold. J. Biol. Chem. 271, 11979 (1996).8662609","journal-title":"J. Biol. Chem."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201981200"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.481"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(92)90636-X"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.10.016"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7973652"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05580"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03327"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1624"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.94"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1949"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.642-658.2003"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175868"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1209368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T13:34:24Z","timestamp":1704893664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1209368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,21]]},"references-count":23,"journal-issue":{"issue":"6054","published-print":{"date-parts":[[2011,10,21]]}},"alternative-id":["10.1126\/science.1209368"],"URL":"https:\/\/doi.org\/10.1126\/science.1209368","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,21]]}}}