{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:59:22Z","timestamp":1779181162021,"version":"3.51.4"},"reference-count":55,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6071","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,2,24]]},"abstract":"<jats:title>Enduring Tolerance<\/jats:title>\n          <jats:p>\n            During an infection, the host organism deploys multiple defense strategies. Disease resistance, the process by which the immune system decreases pathogen burden is perhaps the most well-known, and certainly the mechanism that is best studied and understood. Other defense strategies range from pathogen avoidance, through tolerance of pathogen-induced tissue damage, and endurance of the overall pathogen burden.\n            <jats:bold>\n              Medzhitov\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"936\" related-article-type=\"in-this-issue\" vol=\"335\" xlink:href=\"10.1126\/science.1214935\">936<\/jats:related-article>\n            ) review the concept of disease tolerance and suggest that particularly in animals, it is an overlooked mechanism of host defense.\n          <\/jats:p>","DOI":"10.1126\/science.1214935","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T19:27:41Z","timestamp":1330025261000},"page":"936-941","source":"Crossref","is-referenced-by-count":1501,"title":["Disease Tolerance as a Defense Strategy"],"prefix":"10.1126","volume":"335","author":[{"given":"Ruslan","family":"Medzhitov","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA."}]},{"given":"David S.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Palo Alto, CA 94305, USA."}]},{"given":"Miguel P.","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras 2780-156, Portugal."}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.128.3326.714"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.py.09.090171.001315"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0184"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1148526"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000004"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2432"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2004.03.005"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904464106"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08029"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911934107"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610281104"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04216"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0166"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9165"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2010.0117"},{"key":"e_1_3_1_17_2","unstructured":"P. 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