{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:48:29Z","timestamp":1774907309153,"version":"3.50.1"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6081","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,5,4]]},"abstract":"<jats:title>Small But Perfectly Formed<\/jats:title>\n                  <jats:p>\n                    The imaginal discs of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    represent defined larval tissues that give rise to the subsequent adult appendages. These tissues regenerate in response to damage. When the imaginal discs are injured or show tumor growth, they signal to the rest of the larval animal to slow down growth and delay morphogenesis.\n                    <jats:bold>\n                      Garelli\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"579\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1216735\">579<\/jats:related-article>\n                    ) and\n                    <jats:bold>\n                      Colombani\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"582\" related-article-type=\"in-this-issue\" vol=\"336\" xlink:href=\"10.1126\/science.1216689\">582<\/jats:related-article>\n                    ) now show that an insulin-like peptide, termed Dilp8, is secreted into the hemolymph (insect \u201cblood\u201d) and participates in the communication between growing organs and the endocrine system to adjust the growth program and maturation time. This collaboration ensures that adults attain the normal size and maintain appropriate proportions and symmetry.\n                  <\/jats:p>","DOI":"10.1126\/science.1216735","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T14:11:40Z","timestamp":1336054300000},"page":"579-582","source":"Crossref","is-referenced-by-count":471,"title":["Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation"],"prefix":"10.1126","volume":"336","author":[{"given":"Andres","family":"Garelli","sequence":"first","affiliation":[{"name":"Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Miguel Hern\u00e1ndez de Elche, Sant Joan d\u2019Alacant, 03550 Alicante, Spain."}]},{"given":"Alisson M.","family":"Gontijo","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Miguel Hern\u00e1ndez de Elche, Sant Joan d\u2019Alacant, 03550 Alicante, Spain."}]},{"given":"Veronica","family":"Miguela","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Miguel Hern\u00e1ndez de Elche, Sant Joan d\u2019Alacant, 03550 Alicante, Spain."}]},{"given":"Esther","family":"Caparros","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Miguel Hern\u00e1ndez de Elche, Sant Joan d\u2019Alacant, 03550 Alicante, Spain."}]},{"given":"Maria","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Instituto de Neurociencias, Consejo Superior de Investigaciones Cient\u00edficas\u2013Universidad Miguel Hern\u00e1ndez de Elche, Sant Joan d\u2019Alacant, 03550 Alicante, Spain."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00276-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1990.Supplement_13.16"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.06.033"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4161\/org.6.2.10375"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01682081"},{"key":"e_1_3_2_7_2","first-page":"155","article-title":"The initiation of pupariation in Drosophila: dependence on growth of the imaginal discs","volume":"57","author":"Simpson P.","year":"1980","unstructured":"Simpson P., Berreur P., Berreur-Bonnenfant J., The initiation of pupariation in Drosophila: dependence on growth of the imaginal discs. 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