{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:44:05Z","timestamp":1774507445729,"version":"3.50.1"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6104","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,10,12]]},"abstract":"<jats:title>Distinguishing Right from Left<\/jats:title>\n                  <jats:p>\n                    In most vertebrates during embryonic development, rotational movement of the cilia within a structure in the embryo, known as the node, generates unidirectional flow required for future left-right asymmetry of the internal organs. The flow may transport a determinant molecule or provide mechanical force. However, it is not clear how the flow is sensed.\n                    <jats:bold>\n                      Yoshiba\n                      <jats:italic>et al.<\/jats:italic>\n                    <\/jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"226\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1222538\">226<\/jats:related-article>\n                    , published online 13 September; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6104\" page=\"206\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1230401\">\n                        <jats:bold>Norris and Grimes<\/jats:bold>\n                      <\/jats:related-article>\n                    <\/jats:bold>\n                    ) show that nodal flow in mouse embryos is sensed by the cilia of perinodal cells located at the edge of the node, in a manner dependent on Pkd2, a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -permeable cation channel that has been implicated in polycystic kidney disease in humans.\n                  <\/jats:p>","DOI":"10.1126\/science.1222538","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T06:42:00Z","timestamp":1347691320000},"page":"226-231","source":"Crossref","is-referenced-by-count":285,"title":["Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2"],"prefix":"10.1126","volume":"338","author":[{"given":"Satoko","family":"Yoshiba","sequence":"first","affiliation":[{"name":"Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST), Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, 565-0871 Osaka, Japan."}]},{"given":"Hidetaka","family":"Shiratori","sequence":"additional","affiliation":[{"name":"Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST), Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, 565-0871 Osaka, Japan."}]},{"given":"Ivana Y.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA."}]},{"given":"Aiko","family":"Kawasumi","sequence":"additional","affiliation":[{"name":"Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST), Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, 565-0871 Osaka, Japan."}]},{"given":"Kyosuke","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST), Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, 565-0871 Osaka, Japan."}]},{"given":"Shigenori","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Laboratory for Spatiotemporal Regulations, National Institute for Basic Biology, Nishigonaka 38, Myodaiji, Okazaki, 444-8585 Aichi, Japan."}]},{"given":"Yasuko","family":"Asai","sequence":"additional","affiliation":[{"name":"Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST), Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, 565-0871 Osaka, Japan."}]},{"given":"Genta","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST), Japan Science and Technology Corporation (JST), 1-3 Yamada-oka, Suita, 565-0871 Osaka, Japan."}]},{"given":"Jose Antonio","family":"Belo","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Departamento de Ci\u00eancias Biom\u00e9dicas e Medicina, and IBB-Institute for Biotechnology and Bioengineering, Universidade do Algarve, Campus de Gambelas, 8005-135 Faro, Portugal."}]},{"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan."}]},{"given":"Junichi","family":"Nakai","sequence":"additional","affiliation":[{"name":"Saitama University Brain Science Institute, 255 Shimo-Okubo, Sakura-ku, Saitama 338-8570, Japan."}]},{"given":"Bernd","family":"Dworniczak","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum M\u00fcnster, Institut f\u00fcr Humangenetik, Vesaliusweg 12-14, 48149 M\u00fcnster, Germany."}]},{"given":"Barbara E.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA."}]},{"given":"Petra","family":"Pennekamp","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum M\u00fcnster, Institut f\u00fcr Humangenetik, Vesaliusweg 12-14, 48149 M\u00fcnster, Germany."},{"name":"Universitaetsklinikum Muenster, Klinik f\u00fcr Kinder- und Jugendmedizin, Allgemeine P\u00e4diatrie, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany."}]},{"given":"Hiroshi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka 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