{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:14:37Z","timestamp":1777338877230,"version":"3.51.4"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6109","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2012,11,16]]},"abstract":"<jats:title>\n            Subversive\n            <jats:italic>Salmonella<\/jats:italic>\n          <\/jats:title>\n          <jats:p>\n            <jats:italic>Salmonella<\/jats:italic>\n            is one of the most intensively studied bacterial pathogens. The\n            <jats:italic>Salmonella<\/jats:italic>\n            -containing vacuole (SCV) has a paradoxical lysosome-like composition: On one hand, the SCV membrane is highly enriched in lysosomal membrane glycoproteins and SCVs are accessible to endolysosomal content, but on the other hand, SCV lumen is relatively devoid of lysosomal hydrolytic enzymes that are delivered by the mannose-6-phosphate receptor pathway.\n            <jats:bold>\n              McGourty\n              <jats:italic>et al.<\/jats:italic>\n            <\/jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" page=\"963\" related-article-type=\"in-this-issue\" vol=\"338\" xlink:href=\"10.1126\/science.1227037\">963<\/jats:related-article>\n            ) resolve this paradox by showing that the\n            <jats:italic>Salmonella<\/jats:italic>\n            effector SifA interferes with the trafficking of mannose-6-phosphate receptors. This causes misrouting and secretion of lysosomal enzymes and reduces the hydrolytic activity of lysosomes. Intracellular growth of\n            <jats:italic>Salmonella<\/jats:italic>\n            was reduced in cells with enhanced lysosomal enzyme activity.\n          <\/jats:p>","DOI":"10.1126\/science.1227037","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T20:00:29Z","timestamp":1353009629000},"page":"963-967","source":"Crossref","is-referenced-by-count":185,"title":["<i>Salmonella<\/i>\n            Inhibits Retrograde Trafficking of Mannose-6-Phosphate Receptors and Lysosome Function"],"prefix":"10.1126","volume":"338","author":[{"given":"Kieran","family":"McGourty","sequence":"first","affiliation":[{"name":"Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK."}]},{"given":"Teresa L.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK."}]},{"given":"Sophie A.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK."}]},{"given":"Laurie","family":"Pinaud","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK."}]},{"given":"Lu\u00eds Jaime","family":"Mota","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK."}]},{"given":"David W.","family":"Holden","sequence":"additional","affiliation":[{"name":"Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, 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