{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:13:20Z","timestamp":1774678400111,"version":"3.50.1"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6200","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2014,8,29]]},"abstract":"<jats:title>Rabbits softly swept to domestication<\/jats:title>\n          <jats:p>\n            When people domesticate animals, they select for tameness and tolerance of humans. What else do they look for? To identify the selective pressures that led to rabbit domestication, Carneiro\n            <jats:italic>et al.<\/jats:italic>\n            sequenced a domestic rabbit genome and compared it to that of its wild brethren (see the Perspective by Lohmueller). Domestication did not involve a single gene changing, but rather many gene alleles changing in frequency between tame and domestic rabbits, known as a soft selective sweep. Many of these alleles have changes that may affect brain development, supporting the idea that tameness involves changes at multiple loci.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6200\" page=\"1074\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1253714\">1074<\/jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6200\" page=\"1000\" related-article-type=\"in-this-issue\" vol=\"345\" xlink:href=\"10.1126\/science.1258775\">1000<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.1253714","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T18:25:20Z","timestamp":1409250320000},"page":"1074-1079","source":"Crossref","is-referenced-by-count":359,"title":["Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication"],"prefix":"10.1126","volume":"345","author":[{"given":"Miguel","family":"Carneiro","sequence":"first","affiliation":[{"name":"CIBIO\/InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, Campus Agr\u00e1rio de Vair\u00e3o, Universidade do Porto, 4485-661, Vair\u00e3o, Portugal."}]},{"given":"Carl-Johan","family":"Rubin","sequence":"additional","affiliation":[{"name":"Science for Life Laboratory Uppsala, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden."}]},{"given":"Federica","family":"Di Palma","sequence":"additional","affiliation":[{"name":"Broad Institute of Harvard and 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UK."}]},{"given":"Daniel","family":"Barrell","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, UK."},{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK."}]},{"given":"Gerard","family":"Bolet","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UMR1388 G\u00e9n\u00e9tique, Physiologie et Syst\u00e8mes d\u2019Elevage, F-31326 Castanet-Tolosan, France."}]},{"given":"Samuel","family":"Boucher","sequence":"additional","affiliation":[{"name":"Labovet Conseil, BP539, 85505 Les Herbiers Cedex, France."}]},{"given":"Hern\u00e1n A.","family":"Burbano","sequence":"additional","affiliation":[{"name":"Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany."}]},{"given":"Rita","family":"Campos","sequence":"additional","affiliation":[{"name":"CIBIO\/InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, Campus Agr\u00e1rio de Vair\u00e3o, Universidade do Porto, 4485-661, Vair\u00e3o, Portugal."}]},{"given":"Jean L.","family":"Chang","sequence":"additional","affiliation":[{"name":"Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, MA 02142, USA."}]},{"given":"Veronique","family":"Duranthon","sequence":"additional","affiliation":[{"name":"INRA, UMR1198 Biologie du D\u00e9veloppement et Reproduction, F-78350 Jouy-en-Josas, France."}]},{"given":"Luca","family":"Fontanesi","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Sciences, Division of Animal Sciences, University of Bologna, 40127 Bologna, Italy."}]},{"given":"Herv\u00e9","family":"Garreau","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique (INRA), UMR1388 G\u00e9n\u00e9tique, Physiologie et Syst\u00e8mes d\u2019Elevage, F-31326 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