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Furthermore, only a few tissues have been examined per genetic variant. In order to examine how genetic expression varies among tissues within individuals, the Genotype-Tissue Expression (GTEx) Consortium collected 1641 postmortem samples covering 54 body sites from 175 individuals. They identified quantitative genetic traits that affect gene expression and determined which of these exhibit tissue-specific expression patterns. Mel\u00e9\n et al.<\/jats:italic>\n measured how transcription varies among tissues, and Rivas\n et al.<\/jats:italic>\n looked at how truncated protein variants affect expression across tissues.\n <\/jats:p>\n \n Science<\/jats:italic>\n , this issue p.\n 648<\/jats:related-article>\n , p.\n 660<\/jats:related-article>\n , p.\n 666<\/jats:related-article>\n ; see also p.\n 640<\/jats:related-article>\n <\/jats:p>","DOI":"10.1126\/science.1261877","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T18:11:07Z","timestamp":1431022267000},"page":"666-669","source":"Crossref","is-referenced-by-count":293,"title":["Effect of predicted protein-truncating genetic variants on the human transcriptome"],"prefix":"10.1126","volume":"348","author":[{"given":"Manuel A.","family":"Rivas","sequence":"first","affiliation":[{"name":"Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK."}]},{"given":"Matti","family":"Pirinen","sequence":"additional","affiliation":[{"name":"FInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland."}]},{"given":"Donald F.","family":"Conrad","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis, St. Louis, MO, USA."}]},{"given":"Monkol","family":"Lek","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."},{"name":"Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA."}]},{"given":"Emily K.","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA."},{"name":"Department of Pathology, Stanford University, Stanford, CA, USA."},{"name":"Biomedical Informatics Program, Stanford University, Stanford, CA, USA."}]},{"given":"Konrad J.","family":"Karczewski","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."},{"name":"Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA."}]},{"given":"Julian B.","family":"Maller","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."},{"name":"Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA."}]},{"given":"Kimberly R.","family":"Kukurba","sequence":"additional","affiliation":[{"name":"Department of Genetics, Stanford University, Stanford, CA, USA."},{"name":"Department of Pathology, Stanford University, Stanford, CA, USA."}]},{"given":"David S.","family":"DeLuca","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."}]},{"given":"Menachem","family":"Fromer","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, MA, USA."},{"name":"Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA."},{"name":"Department of Psychiatry, Mt. 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