{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:54:30Z","timestamp":1761918870861},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"4460","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1980,8,29]]},"abstract":"<jats:p>Mononuclear cells from peripheral blood of normal humans, unselected spleen cells from patients with Hodgkin's disease, and selected T and non-T lymphoid cells from normal peripheral blood and from the spleens of Hodgkin's disease patients were examined for de novo synthesis and secretion of ferritin. After precipitation of labeled lysates and supernatants from unseparated and selected T cells with antiserum to human liver ferritin, two bands were visible on sodium dodecyl sulfate-polyacrylimide gel analysis. The two bands were detected in molecular weight regions 19,000 and 21,000, which are thought to represent the L and H subunits of the ferritin molecule, respectively. The slower band (subunit H) was more radioactive than the faster band (subunit L). The H subunit is found in greater amounts in the serum of some tumor patients, but its cellular origin has not been established. The present findings indicate that cells of the immune system contribute to the synthesis and secretion of a ferritin molecule with a high proportion of H subunits.<\/jats:p>","DOI":"10.1126\/science.6967622","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T13:45:58Z","timestamp":1160055958000},"page":"1019-1021","source":"Crossref","is-referenced-by-count":65,"title":["Ferritin Synthesis by Human T Lymphocytes"],"prefix":"10.1126","volume":"209","author":[{"given":"Marianne H.","family":"D\u00f6rner","sequence":"first","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York 10021"}]},{"given":"Allen","family":"Silverstone","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York 10021"}]},{"given":"Koji","family":"Nishiya","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York 10021"}]},{"given":"Anne","family":"de Sostoa","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York 10021"}]},{"given":"Gwyneth","family":"Munn","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York 10021"}]},{"given":"Maria","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York 10021"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1016\/S0021-9258(17)34741-5","volume":"253","year":"1978","unstructured":"AROSIO, P, FERRITIN HETEROGENEITY - FURTHER EVIDENCE FOR HETEROPOLYMERS, JOURNAL OF BIOLOGICAL CHEMISTRY 253: 4451 (1978).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/00365516809076979","volume":"21","year":"1968","unstructured":"BOYUM, A, ISOLATION OF MONONUCLEAR CELLS AND GRANULOCYTES FROM HUMAN BLOOD - ISOLATION OF MONONUCLEAR CELLS BY ONE CENTRIFUGATION AND OF GRANULOCYTES BY COMBINING CENTRIFUGATION AND SEDIMENTATION AT L G, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 21: 77 (1968).","journal-title":"SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1182\/blood.V55.2.324.324","volume":"55","year":"1980","unstructured":"BROXMEYER, H.E., SPECIFICITY AND MODULATION OF THE ACTION OF LACTOFERRIN, A NEGATIVE FEEDBACK REGULATOR OF MYELOPOIESIS, BLOOD 55: 324 (1980).","journal-title":"BLOOD"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1084\/jem.148.4.1052","volume":"148","year":"1978","unstructured":"BROXMEYER, H.E., IDENTIFICATION OF LACTOFERRIN AS GRANULOCYTE-DERIVED INHIBITOR OF COLONY-STIMULATING ACTIVITY PRODUCTION, JOURNAL OF EXPERIMENTAL MEDICINE 148: 1052 (1978).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_5_1","first-page":"342","volume":"33","year":"1973","unstructured":"CHANDLER, F.W., RADIOIRON INCORPORATION BY A TRANSPLANTABLE LYMPHOID TUMOR, CANCER RESEARCH 33: 342 (1973).","journal-title":"CANCER RESEARCH"},{"key":"e_1_2_1_6_1","first-page":"605","year":"1979","unstructured":"CUNNINGHAMRUNDL.S, MOL BASIS IMMUNE CEL: 605 (1979).","journal-title":"MOL BASIS IMMUNE CEL"},{"key":"e_1_2_1_7_1","first-page":"497","volume":"90","year":"1978","unstructured":"DESOUSA, M, SUGGESTED MODELS OF ECOTAXOPATHY IN LYMPHORETICULAR MALIGNANCY - ROLE FOR IRON-BINDING PROTEINS IN CONTROL OF LYMPHOID-CELL MIGRATION, AMERICAN JOURNAL OF PATHOLOGY 90: 497 (1978).","journal-title":"AMERICAN JOURNAL OF PATHOLOGY"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0008-8749(78)90048-5","volume":"38","year":"1978","unstructured":"DESOUSA, M, CELL IMMUNOL 38: 203 (1978).","journal-title":"CELL IMMUNOL"},{"key":"e_1_2_1_9_1","unstructured":"Dorner M. 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