{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:19:20Z","timestamp":1792070360415,"version":"4.4.0"},"reference-count":10,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6230","license":[{"start":{"date-parts":[[2016,4,3]],"date-time":"2016-04-03T00:00:00Z","timestamp":1459641600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.sciencemag.org\/about\/science-licenses-journal-article-reuse"}],"funder":[{"name":"Caribou Biosciences, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2015,4,3]]},"abstract":"<jats:p>A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed<\/jats:p>","DOI":"10.1126\/science.aab1028","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T11:08:12Z","timestamp":1426849692000},"page":"36-38","source":"Crossref","is-referenced-by-count":525,"title":["A prudent path forward for genomic engineering and germline gene modification"],"prefix":"10.1126","volume":"348","author":[{"given":"David","family":"Baltimore","sequence":"first","affiliation":[{"name":"California Institute of Technology, Mail Code 147-75, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Berg","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94305, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Botchan","sequence":"additional","affiliation":[{"name":"University of California, Berkeley, 450 Li Ka Shing no. 3370, Berkeley, CA 94720-3370, USA."},{"name":"Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Room 4100, Salt Lake City, UT 84112-5650, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Alta","family":"Charo","sequence":"additional","affiliation":[{"name":"Department of Medical History and Bioethics, School of Medicine and Public Health, University of Wisconsin Law School, 975 Bascom Mall, Madison, WI 53706, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Corn","sequence":"additional","affiliation":[{"name":"Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Q.","family":"Daley","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital, 300 Longwood Avenue, Karp Family Building, 7th Floor, Boston, MA 02115, USA."},{"name":"Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Doudna","sequence":"additional","affiliation":[{"name":"Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA."},{"name":"Departments of Molecular and Cell Biology and Chemistry, Howard Hughes Medical Institute, 731 Stanley Hall, MS 3220, University of California, Berkeley, Berkeley, CA 94720-3220, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha","family":"Fenner","sequence":"additional","affiliation":[{"name":"Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry T.","family":"Greely","sequence":"additional","affiliation":[{"name":"Center for Law and the Biosciences, Crown Quadrangle 559 Nathan Abbott Way Stanford, CA 94305-8610, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jinek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Steven","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, College of Letters and Science, University of California, Berkeley, 210K Durant Hall, Berkeley, CA 94720-2920, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Penhoet","sequence":"additional","affiliation":[{"name":"Alta Partners, One Embarcadero Center, 37th Floor, San Francisco, CA 94111, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Puck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, CA 94143, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel H.","family":"Sternberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry, 731 Stanley Hall, MS 3220, University of California, Berkeley, CA 94720-3220, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Weissman","sequence":"additional","affiliation":[{"name":"Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA."},{"name":"Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, Byers Hall, 1700 4th Street, San Francisco, CA 94158-2330, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R.","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Innovative Genomics Initiative, University of California, Berkeley, 188 Li Ka Shing Center, Berkeley, CA 94720-3370, USA."},{"name":"UCSF School of Medicine, 600 16th Street, San Francisco, CA 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258096"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2884"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232033"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801185-0.00011-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.025"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.027"},{"key":"e_1_3_2_9_2","unstructured":"www.hfea.gov.uk\/8807.html"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11647"},{"key":"e_1_3_2_11_2","unstructured":"The Human Fertilisation and Embryology (Mitochondrial Donation) Regulations 2015 ; www.legislation.gov.uk\/uksi\/2015\/572\/contents\/made (effective 29 October 2015)."},{"key":"e_1_3_2_12_2","unstructured":"U.S. Food and Drug Administration Cellular Tissue and Gene Therapies Advisory Committee Meeting: Announcement www.fda.gov\/AdvisoryCommittees\/Calendar\/ucm380042.htm; www.iom.edu\/activities\/research\/mitoethics.aspx."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aab1028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T12:51:44Z","timestamp":1705323104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aab1028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,3]]},"references-count":10,"journal-issue":{"issue":"6230","published-print":{"date-parts":[[2015,4,3]]}},"alternative-id":["10.1126\/science.aab1028"],"URL":"https:\/\/doi.org\/10.1126\/science.aab1028","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,3]]}}}