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The CRISPR-Cas system has been adapted for facile genome editing, heralding a new age in molecular biology. Jiang\n            <jats:italic>et al.<\/jats:italic>\n            show that the Cas9 nuclease adopts a distinct confirmation when it binds to the targeting guide RNA. The guide RNA then assumes a preordered shape. This RNA \u201cseed region\u201d is thus poised to initiate recognition of the DNA target sequence.\n          <\/jats:p>\n          <jats:p>\n            <jats:italic>Science<\/jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6242\" page=\"1477\" related-article-type=\"in-this-issue\" vol=\"348\" xlink:href=\"10.1126\/science.aab1452\">1477<\/jats:related-article>\n          <\/jats:p>","DOI":"10.1126\/science.aab1452","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T18:15:05Z","timestamp":1435256105000},"page":"1477-1481","source":"Crossref","is-referenced-by-count":564,"title":["A Cas9\u2013guide RNA complex preorganized for target DNA recognition"],"prefix":"10.1126","volume":"348","author":[{"given":"Fuguo","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California, 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