{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:30:08Z","timestamp":1772850608076,"version":"3.50.1"},"reference-count":34,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6490","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31DK107256"],"award-info":[{"award-number":["F31DK107256"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31GM117854"],"award-info":[{"award-number":["F31GM117854"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK113791"],"award-info":[{"award-number":["R01DK113791"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI131659"],"award-info":[{"award-number":["R21AI131659"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16GRNT31460005"],"award-info":[{"award-number":["16GRNT31460005"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>IL-13 hits the gym<\/jats:title>\n                  <jats:p>\n                    Interleukin-13 (IL-13) is a cytokine secreted by T cells, innate lymphoid cells (ILC2s), and granulocytes. It acts as a central mediator in allergy and antihelminth defense with various effects. Knudsen\n                    <jats:italic>et al.<\/jats:italic>\n                    report a distinct role for IL-13 in exercise and metabolism (see the Perspective by Correia and Ruas). Mice subjected to endurance training showed increases in circulating IL-13, which correlated with ILC2 expansion in the muscles. By contrast, exercise-induced increases in muscle fatty acid utilization and mitochondrial biogenesis were erased when mice lacked IL-13. Activation of signaling pathways downstream of the muscle IL-13 receptor was key to this effect. Intramuscular injection of adenoviral IL-13 could recapitulate exercise-induced metabolic reprogramming. This signaling pathway may have evolved to combat the metabolic stresses of parasite infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126\/science.aat3987\">eaat3987<\/jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" issue=\"6490\" page=\"470\" related-article-type=\"in-this-issue\" vol=\"368\" xlink:href=\"10.1126\/science.abb4116\">470<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.aat3987","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T19:05:17Z","timestamp":1588273517000},"source":"Crossref","is-referenced-by-count":116,"title":["Interleukin-13 drives metabolic conditioning of muscle to endurance exercise"],"prefix":"10.1126","volume":"368","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0384-1097","authenticated-orcid":true,"given":"Nelson H.","family":"Knudsen","sequence":"first","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. 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Chan School of Public Health, Boston, MA 02115, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9204-9586","authenticated-orcid":true,"given":"Ryan K.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-7318","authenticated-orcid":true,"given":"Yae-Huei","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-958X","authenticated-orcid":true,"given":"Kyle A.","family":"Starost","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"given":"Matthew R.","family":"Gangl","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-223X","authenticated-orcid":true,"given":"David","family":"Jacobi","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"given":"Sihao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"given":"Danesh H.","family":"Sopariwala","sequence":"additional","affiliation":[{"name":"Metabolic and Degenerative Diseases, Institute of Molecular Medicine, University of Texas McGovern Medical School, Houston, TX 77030, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7400-9804","authenticated-orcid":true,"given":"Diogo","family":"Fonseca-Pereira","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-8638","authenticated-orcid":true,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA 02115, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-0150","authenticated-orcid":true,"given":"Wendy S.","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA."},{"name":"Department of Immunology and Infectious Diseases, Harvard T. H. 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