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Its main protease, M\n                    <jats:sup>pro<\/jats:sup>\n                    , is essential to yield functional viral proteins, making it a key drug target. G\u00fcnther\n                    <jats:italic>et al.<\/jats:italic>\n                    used x-ray crystallography to screen more than 5000 compounds that are either approved drugs or drugs in clinical trials. The screen identified 37 compounds that bind to M\n                    <jats:sup>pro<\/jats:sup>\n                    . High-resolution structures showed that most compounds bind at the active site but also revealed two allosteric sites where binding of a drug causes conformational changes that affect the active site. In cell-based assays, seven compounds had antiviral activity without toxicity. The most potent, calpeptin, binds covalently in the active site, whereas the second most potent, pelitinib, binds at an allosteric site.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Science<\/jats:italic>\n                    , this issue p.\n                    <jats:related-article issue=\"6542\" page=\"642\" related-article-type=\"in-this-issue\" vol=\"372\">642<\/jats:related-article>\n                  <\/jats:p>","DOI":"10.1126\/science.abf7945","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T11:05:11Z","timestamp":1617361511000},"page":"642-646","source":"Crossref","is-referenced-by-count":339,"title":["X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease"],"prefix":"10.1126","volume":"372","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-6653","authenticated-orcid":true,"given":"Sebastian","family":"G\u00fcnther","sequence":"first","affiliation":[{"name":"Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-0839","authenticated-orcid":true,"given":"Patrick Y. 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