{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:47:45Z","timestamp":1774874865328,"version":"3.50.1"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6568","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2021,11,5]]},"abstract":"<jats:title>Synapse stabilization<\/jats:title>\n          <jats:p>\n            Early in brain development, neurons connect to each other enthusiastically. With development, an overabundance of synapses is winnowed down to refine efficiently connected circuits. Inactive synapses are prime targets for elimination, whereas active synapses tend to be retained. Gomez-Castro\n            <jats:italic>et al<\/jats:italic>\n            . took a closer look at how those choices are made (see the Perspective by Blum and Lopes). When postsynaptic adenosine receptors are muted or do not find enough extracellular adenosine, synapses get eliminated. Neurotransmitter-dependent signaling pathways drive protein kinase A to phosphorylate the postsynaptic scaffolding molecule gephyrin. Together with a partner synaptogenic membrane protein, gephyrin is required for the stabilization of \u03b3-aminobutyric acid receptors. Adenosine receptors thus detect synaptic activity and in turn drive the stabilization of synapses that produce such activity. \u2014PJH\n          <\/jats:p>","DOI":"10.1126\/science.abk2055","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T17:57:25Z","timestamp":1636048645000},"source":"Crossref","is-referenced-by-count":71,"title":["Convergence of adenosine and GABA signaling for synapse stabilization during development"],"prefix":"10.1126","volume":"374","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-2416","authenticated-orcid":true,"given":"Ferran","family":"Gomez-Castro","sequence":"first","affiliation":[{"name":"INSERM UMR-S 1270, Sorbonne Universit\u00e9, Institut du Fer \u00e0 Moulin, Paris, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-9573","authenticated-orcid":true,"given":"Stefania","family":"Zappettini","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, INSERM, INS, Institut de 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