{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:56:56Z","timestamp":1776225416058,"version":"3.50.1"},"reference-count":58,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6584","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2022,3,4]]},"abstract":"<jats:p>\n                    For more than 100 years, the fruit fly\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula\n                    <jats:italic>Drosophilae<\/jats:italic>\n                    , that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to &gt;250 distinct cell types. We provide an in-depth analysis of cell type\u2013related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.\n                  <\/jats:p>","DOI":"10.1126\/science.abk2432","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T13:55:57Z","timestamp":1646315757000},"source":"Crossref","is-referenced-by-count":736,"title":["Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly"],"prefix":"10.1126","volume":"375","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-7122","authenticated-orcid":true,"given":"Hongjie","family":"Li","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA."},{"name":"Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA."},{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-0782","authenticated-orcid":true,"given":"Jasper","family":"Janssens","sequence":"additional","affiliation":[{"name":"VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven 3000, Belgium."},{"name":"Laboratory of Computational Biology, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-3737","authenticated-orcid":true,"given":"Maxime","family":"De Waegeneer","sequence":"additional","affiliation":[{"name":"VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven 3000, Belgium."},{"name":"Laboratory of Computational Biology, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium."}]},{"given":"Sai Saroja","family":"Kolluru","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Stanford University, Stanford, CA, USA."},{"name":"Department of Applied Physics, Stanford University, Stanford, CA, USA."},{"name":"Chan Zuckerberg Biohub, San Francisco CA, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-1249","authenticated-orcid":true,"given":"Kristofer","family":"Davie","sequence":"additional","affiliation":[{"name":"VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven 3000, Belgium."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8954-2161","authenticated-orcid":true,"given":"Vincent","family":"Gardeux","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland."},{"name":"Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7114-6248","authenticated-orcid":true,"given":"Wouter","family":"Saelens","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland."},{"name":"Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8539-865X","authenticated-orcid":true,"given":"Fabrice P. 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