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We assembled genomic, metabolic, and ecological data from nearly all known species of the ancient fungal subphylum Saccharomycotina (1154 yeast strains from 1051 species), grown in 24 different environmental conditions, to examine niche breadth evolution. We found that large differences in the breadth of carbon utilization traits between yeasts stem from intrinsic differences in genes encoding specific metabolic pathways, but we found limited evidence for trade-offs. These comprehensive data argue that intrinsic factors shape niche breadth variation in microbes.<\/jats:p>","DOI":"10.1126\/science.adj4503","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T18:00:04Z","timestamp":1714068004000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":113,"title":["Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts"],"prefix":"10.1126","volume":"384","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3224-7510","authenticated-orcid":true,"given":"Dana A.","family":"Opulente","sequence":"first","affiliation":[{"name":"Laboratory of Genetics, Wisconsin Energy Institute, Center for Genomic Science Innovation, J. F. 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