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We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid cycling. During the sleep phase, the adipocyte clock suppresses\n                    <jats:italic toggle=\"yes\">Slc25a34<\/jats:italic>\n                    expression through the REV-ERB transcriptional repressors. Entering the active phase, consuming lipid-rich diets, or exposure to cold abolishes REV-ERB repression, and lipolytic signals stimulate\n                    <jats:italic toggle=\"yes\">Slc25a34<\/jats:italic>\n                    transcription through the peroxisome proliferator\u2013activated receptors. SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl\u2013coenzyme A (acetyl-CoA) production. Elevated cytosolic acetyl-CoA then fuels the synthesis of lipids and promotes the transcription of genes enhancing mitochondrial oxidation. Thus, SLC25A34 confers circadian, dietary, and temperature control of adipocyte lipid metabolism.\n                  <\/jats:p>","DOI":"10.1126\/science.adz4797","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:00:47Z","timestamp":1790877647000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling"],"prefix":"10.1126","volume":"394","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-2585","authenticated-orcid":true,"given":"Iuliia","family":"Karavaeva","sequence":"first","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-9232","authenticated-orcid":true,"given":"Astrid Linde","family":"Basse","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark."},{"name":"Center for Adipocyte Signaling (ADIPOSIGN), University of Southern Denmark, Odense, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-4094","authenticated-orcid":true,"given":"Samuel A. 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