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Cryo\u2013electron microscopy confirmed that a generated phage utilizes an evolutionarily distant DNA packaging protein in its capsid. A cocktail of generated phages rapidly overcomes \u03a6X174-resistant\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    strains, demonstrating a path toward artificial intelligence\u2013generated phage therapies against rapidly evolving bacterial pathogens. This work provides a blueprint for the design of diverse synthetic bacteriophages and useful biological systems at the genome scale.\n                  <\/jats:p>","DOI":"10.1126\/science.aec2657","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:00:38Z","timestamp":1786039238000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Generative design of bacteriophages with genome language models"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-5045","authenticated-orcid":true,"given":"Samuel H.","family":"King","sequence":"first","affiliation":[{"name":"Department of Bioengineering, Stanford University, Stanford, CA, USA."},{"name":"Arc Institute, Palo Alto, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-6910","authenticated-orcid":true,"given":"Claudia 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