{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:59:14Z","timestamp":1790276354908,"version":"4.1.0"},"reference-count":114,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"6818","funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005237","name":"Helen Hay Whitney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005348","name":"American Association for Thoracic Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017050","name":"Cycle for Survival","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019664","name":"Expect Miracles Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009859","name":"Geoffrey Beene Cancer Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009859","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015127","name":"Commonwealth Foundation for Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017556","name":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017556","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Science"],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:p>Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are conserved drivers of fibrosis and therapeutic targets, yet their functional heterogeneity complicates therapeutic intervention. Here, we show that P-selectin is expressed by a subset of senescent-like cells in fibrotic tissues and tumors. Leveraging fucoidan-based nanoparticles that bind P-selectin, we developed senescence-modulating nanoparticles (SMNPs) to selectively target these disease-associated states. SMNPs exerted potent antifibrotic and immunomodulatory effects while improving the therapeutic index. Mechanistically, we identified a pathogenic, immunosuppressive macrophage population as a functional target in vivo. In fibrotic tumors, niche remodeling restored immune infiltration and sensitized tumors to immune checkpoint\u2013based therapies. These findings establish SMNPs as a generalizable strategy to target pathogenic senescent cell subsets across fibrosis and cancer.<\/jats:p>","DOI":"10.1126\/science.aeg4791","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:00:41Z","timestamp":1790272841000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer"],"prefix":"10.1126","volume":"393","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5805-6153","authenticated-orcid":true,"given":"Clemens","family":"Hinterleitner","sequence":"first","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-3594","authenticated-orcid":true,"given":"Valentin J. A.","family":"Barthet","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4830-5626","authenticated-orcid":true,"given":"Hailey V.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."},{"name":"Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5404-3442","authenticated-orcid":true,"given":"Kristen C.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA."},{"name":"Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-8142","authenticated-orcid":true,"given":"Ana Marie","family":"Perea","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA."},{"name":"Cancer Engineering Program, Gerstner Sloan Kettering School for Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3614-3160","authenticated-orcid":true,"given":"Logan R.","family":"Hillger","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-9798","authenticated-orcid":true,"given":"Stephen","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA."},{"name":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-5873","authenticated-orcid":true,"given":"Domhnall","family":"McHugh","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7540-024X","authenticated-orcid":true,"given":"Yu-Jui","family":"Ho","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Chaves-Perez","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-4521","authenticated-orcid":true,"given":"Maria","family":"Skamagki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Flowers","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9339-4254","authenticated-orcid":true,"given":"Hannah C.","family":"Styers","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."},{"name":"Cancer Engineering Program, Gerstner Sloan Kettering School for Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5801-3144","authenticated-orcid":true,"given":"Natasha","family":"Rekhtman","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-3223","authenticated-orcid":true,"given":"Xueqian","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-0990","authenticated-orcid":true,"given":"Gabriel","family":"Dessotti Barretto","sequence":"additional","affiliation":[{"name":"Flow Cytometry Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7422-251X","authenticated-orcid":true,"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0107-1366","authenticated-orcid":true,"given":"Jadae T.","family":"Watson","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luan","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Simon","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-6961","authenticated-orcid":true,"given":"Tuomas","family":"Tammela","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-5136","authenticated-orcid":true,"given":"Rui","family":"Gardner","sequence":"additional","affiliation":[{"name":"Flow Cytometry Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-3465","authenticated-orcid":true,"given":"Charles M.","family":"Rudin","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA."},{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-2903","authenticated-orcid":true,"given":"Paul B.","family":"Romesser","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA."},{"name":"Early Drug Development Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-4028","authenticated-orcid":true,"given":"Matthew J.","family":"Bott","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-8147","authenticated-orcid":true,"given":"Aveline","family":"Filliol","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-0000","authenticated-orcid":true,"given":"Daniel A.","family":"Heller","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY, USA."},{"name":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5284-9650","authenticated-orcid":true,"given":"Scott W.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."},{"name":"Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2938-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32285"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705751"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01070-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1300575"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00429-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.85"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-025-00798-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0749-z"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh8005"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00727-x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2403-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05535-x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14532"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2026.03.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2233"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.049"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3823"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211053698"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060301"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.039"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0426"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0428"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50441-7"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3195"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.05.006"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12445"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1475828"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01287-6"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00480-4"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0092-9"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25453-2"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.09.021"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.12.052"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(16)00021-1"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.2292"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(03)00071-6"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08050-9"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5186"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307437"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.008"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01481-9"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu2292"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf7374"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00738-8"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00601-z"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183653"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1543-4"},{"key":"e_1_3_2_54_2","first-page":"185","article-title":"The pathogenesis of bleomycin-induced pulmonary fibrosis in mice","volume":"77","author":"Adamson I. Y.","year":"1974","unstructured":"I. Y. Adamson, D. H. Bowden, The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Am. J. Pathol. 77, 185\u2013197 (1974). 4141224","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.191"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2004.11.009"},{"key":"e_1_3_2_58_2","first-page":"527","article-title":"Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis","volume":"148","author":"Zhang H. Y.","year":"1996","unstructured":"H. Y. Zhang, M. Gharaee-Kermani, K. Zhang, S. Karmiol, S. H. Phan, Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 148, 527\u2013537 (1996). 8579115","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_59_2","first-page":"2284","article-title":"Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved","volume":"55","author":"Wang E.","year":"1995","unstructured":"E. Wang, Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res. 55, 2284\u20132292 (1995). 7757977","journal-title":"Cancer Res."},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11190"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0217"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.02.216"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19343-9"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0140"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-014-0110-9"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-024-01420-8"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01180-1"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-23-0065"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2006.09.010"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.02.039"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.05.004"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0844-5"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.07.030"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.01.002"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57024-0"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.04.008"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add8945"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20240957"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.015"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.95"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-025-01021-1"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.05.025"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05400-x"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06021-6"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01047-4"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0901"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11843-0"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.07.007"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00668-4"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-025-00907-0"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03811-8"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08000-5"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108444"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008017"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3807"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.11.020"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10334"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.12.002"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(04)00085-6"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18600"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas9090"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0528"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-1425"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26429"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.017"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08285-0"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209620"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl5197"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-1183"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2435-4"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa802"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.aeg4791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:03:01Z","timestamp":1790272981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.aeg4791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":114,"journal-issue":{"issue":"6818","published-print":{"date-parts":[[2026,9,24]]}},"alternative-id":["10.1126\/science.aeg4791"],"URL":"https:\/\/doi.org\/10.1126\/science.aeg4791","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"2026-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaeg4791"}}