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Immunol."],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:p>\u03b3\u03b4 T cells are promising players in immunotherapy because of pleiotropic functions, many of which can be preprogrammed in the thymus. Here, we review the cellular and molecular mechanisms that underlie \u03b3\u03b4 T cell development in the mouse and human thymi, focusing on their acquisition of diverse cytotoxic or cytokine-secreting functions and their dependence on interactions with the specialized thymic epithelium. 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