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Genetic deletion or pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD\n                    <jats:sup>+<\/jats:sup>\n                    synthesis, impaired trained immunity and associated antitumor activity. Nicotinamide mononucleotide (NMN) supplementation rescued defective trained immunity\u2013mediated antitumor activity in NAMPT-deficient and aged mice. In human cancer, NAMPT expression in myeloid cells correlated with an inflammatory tumor microenvironment. Our findings identify KDM5A as a nuclear NAD\n                    <jats:sup>+<\/jats:sup>\n                    sensor that orchestrates histone methylation and chromatin accessibility required for trained immunity.\n                  <\/jats:p>","DOI":"10.1126\/sciimmunol.aea5625","type":"journal-article","created":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:00:01Z","timestamp":1793383201000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Nuclear NAD\n                    <sup>+<\/sup>\n                    promotes innate immune memory by inhibiting KDM5A-dependent histone demethylation"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4935-3704","authenticated-orcid":true,"given":"Huan","family":"Jin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen 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