{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T20:55:00Z","timestamp":1776545700128,"version":"3.51.2"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"332","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>With the discovery of an isoform based on an alternative translation start site, PTEN nomenclature needs an update.<\/jats:p>","DOI":"10.1126\/scisignal.2005560","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T08:45:06Z","timestamp":1404290706000},"source":"Crossref","is-referenced-by-count":59,"title":["A Unified Nomenclature and Amino Acid Numbering for Human PTEN"],"prefix":"10.1126","volume":"7","author":[{"given":"Rafael","family":"Pulido","sequence":"first","affiliation":[{"name":"Ikerbasque, Basque Foundation for Science, Bilbao, Spain."},{"name":"BioCruces Health Research Institute, Barakaldo, Spain."}]},{"given":"Suzanne J.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, USA."}]},{"given":"Joao T.","family":"Barata","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal."}]},{"given":"Arkaitz","family":"Carracedo","sequence":"additional","affiliation":[{"name":"Ikerbasque, Basque Foundation for Science, Bilbao, Spain."},{"name":"CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV\/EHU), Bilbao, Spain."}]},{"given":"Victor J.","family":"Cid","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain."}]},{"given":"Ian D.","family":"Chin-Sang","sequence":"additional","affiliation":[{"name":"Department of Biology, Queen\u2019s University, Kingston, Ontario, Canada."}]},{"given":"Vrushank","family":"Dav\u00e9","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA."}]},{"given":"Jeroen","family":"den Hertog","sequence":"additional","affiliation":[{"name":"Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands."}]},{"given":"Peter","family":"Devreotes","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA."}]},{"given":"Britta J.","family":"Eickholt","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German."}]},{"given":"Charis","family":"Eng","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA."}]},{"given":"Frank B.","family":"Furnari","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA."}]},{"given":"Maria-Magdalena","family":"Georgescu","sequence":"additional","affiliation":[{"name":"The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA."}]},{"given":"Arne","family":"Gericke","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA."}]},{"given":"Benjamin","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}]},{"given":"Xeujun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA."}]},{"given":"Seung-Rock","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea."}]},{"given":"Mathias","family":"L\u00f6sche","sequence":"additional","affiliation":[{"name":"Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh,  PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA."}]},{"given":"Prerna","family":"Malaney","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA."}]},{"given":"Xavier","family":"Matias-Guiu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Genetics\/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain."}]},{"given":"Mar\u00eda","family":"Molina","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ram\u00f3n y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain."}]},{"given":"Pier Paolo","family":"Pandolfi","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA."}]},{"given":"Ramon","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA."}]},{"given":"Paolo","family":"Pinton","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy."}]},{"given":"Carmen","family":"Rivas","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Celular, Centro Nacional de Biotecnolog\u00eda-CSIC, Madrid, Spain; Centro de Investigaci\u00f3n en Medicina Molecular y Enfermedades Cr\u00f3nicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain."}]},{"given":"Rafael M.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, S\u00e3o Paulo, Brazil."}]},{"given":"Manuel S.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebasti\u00e1n, Spain."}]},{"given":"Alonzo H.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA."}]},{"given":"Manuel","family":"Serrano","sequence":"additional","affiliation":[{"name":"Spanish National Cancer Research Center (CNIO), Madrid, Spain."}]},{"given":"Vuk","family":"Stambolic","sequence":"additional","affiliation":[{"name":"Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada."}]},{"given":"Bangyan","family":"Stiles","sequence":"additional","affiliation":[{"name":"Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA."}]},{"given":"Akira","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan."}]},{"given":"Seong-Seng","family":"Tan","sequence":"additional","affiliation":[{"name":"Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia."}]},{"given":"Nicholas K.","family":"Tonks","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA."}]},{"given":"Lloyd C.","family":"Trotman","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA."}]},{"given":"Nicolas","family":"Wolff","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unit\u00e9 de R\u00e9sonance Magn\u00e9tique Nucl\u00e9aire des Biomol\u00e9cules, D\u00e9partement de Biologie Structurale et Chimie, CNRS, Paris, France."}]},{"given":"Rudiger","family":"Woscholski","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK."}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China."}]},{"given":"Nicholas R.","family":"Leslie","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK."}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","first-page":"2124","article-title":"TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta","volume":"57","author":"Li D. M.","year":"1997","unstructured":"Li D. M., Sun H., TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res. 57, 2124\u20132129 (1997).9187108","journal-title":"Cancer Res."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5308.1943"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0497-356"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3330"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3037"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31364"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2012.05.004"},{"key":"e_1_3_1_9_2","unstructured":"COSMIC (Catalogue of Somatic Mutations in Cancer) http:\/\/cancer.sanger.ac.uk\/cancergenome\/projects\/cosmic\/."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr337"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81663-3"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234907"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.023"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb70267g"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.027"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(03)01225-0"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(00)00353-8"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(01)00509-X"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.9.3410"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-006-9293-z"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1242541"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210175"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E06-05-0380"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031839"},{"key":"e_1_3_1_25_2","unstructured":"HGVS www.hgvs.org\/mutnomen\/recs-prot.html."},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.384"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13375"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13513"}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.2005560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T13:14:43Z","timestamp":1705410883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.2005560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":27,"journal-issue":{"issue":"332","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1126\/scisignal.2005560"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.2005560","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}