{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T07:25:32Z","timestamp":1768029932590,"version":"3.49.0"},"reference-count":60,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"514","funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["award298427"],"award-info":[{"award-number":["award298427"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-BSV2-0025-01"],"award-info":[{"award-number":["ANR-12-BSV2-0025-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["award298428"],"award-info":[{"award-number":["award298428"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-FCT 12-ISV3-0002-01"],"award-info":[{"award-number":["ANR-FCT 12-ISV3-0002-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["award298429"],"award-info":[{"award-number":["award298429"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["INFORM Labex ANR-11-LABX-0054\u00c2\u00a0"],"award-info":[{"award-number":["INFORM Labex ANR-11-LABX-0054\u00c2\u00a0"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["award298430"],"award-info":[{"award-number":["award298430"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["DCBIOL Labex ANR-11-LABEX-0043"],"award-info":[{"award-number":["DCBIOL Labex ANR-11-LABEX-0043"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00c3\u00a9dicale","doi-asserted-by":"publisher","award":["award298431"],"award-info":[{"award-number":["award298431"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00c3\u00a9dicale","doi-asserted-by":"publisher","award":["DEQ20140329536"],"award-info":[{"award-number":["DEQ20140329536"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sci. Signal."],"published-print":{"date-parts":[[2018,1,23]]},"abstract":"<jats:p>Guanabenz attenuates autoimmune inflammation by preventing TLR9 from reaching endosomes and becoming fully activated.<\/jats:p>","DOI":"10.1126\/scisignal.aam8104","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:24:39Z","timestamp":1516793079000},"source":"Crossref","is-referenced-by-count":18,"title":["Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2\u03b1 dephosphorylation by the GADD34\/PP1c complex"],"prefix":"10.1126","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-2515","authenticated-orcid":false,"given":"Jessica","family":"Perego","sequence":"first","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1926-376X","authenticated-orcid":false,"given":"Andreia","family":"Mendes","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."},{"name":"International Associated Laboratory (LIA) CNRS \u201cMistra,\u201d 13008 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-4680","authenticated-orcid":false,"given":"Clarisse","family":"Bourbon","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-6279","authenticated-orcid":false,"given":"Voahirana","family":"Camosseto","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."},{"name":"International Associated Laboratory (LIA) CNRS \u201cMistra,\u201d 13008 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-6542","authenticated-orcid":false,"given":"Alexis","family":"Combes","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-1308","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Sanofi, Cambridge, MA 02139, USA."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-342X","authenticated-orcid":false,"given":"Thien-Phong Vu","family":"Manh","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."}]},{"given":"Alexandre","family":"Dalet","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."}]},{"given":"Lionel","family":"Chasson","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-8141","authenticated-orcid":false,"given":"Lionel","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3680-082X","authenticated-orcid":false,"given":"Nathalie","family":"Bardin","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Immunologie, H\u00f4pital de la Conception, 13005 Marseille, France."},{"name":"Aix Marseille Universit\u00e9, INSERM, VRCM, 13005 Marseille, France."}]},{"given":"Laurent","family":"Chiche","sequence":"additional","affiliation":[{"name":"H\u00f4pital Europ\u00e9en, 13003 Marseille, France."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-1146","authenticated-orcid":false,"given":"Manuel A. S.","family":"Santos","sequence":"additional","affiliation":[{"name":"International Associated Laboratory (LIA) CNRS \u201cMistra,\u201d 13008 Marseille, France."},{"name":"Institute for Research in Biomedicine (iBiMED) and Aveiro Health Sciences Program University of Aveiro, 3810-193 Aveiro, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0667-0799","authenticated-orcid":false,"given":"Evelina","family":"Gatti","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."},{"name":"International Associated Laboratory (LIA) CNRS \u201cMistra,\u201d 13008 Marseille, France."},{"name":"Institute for Research in Biomedicine (iBiMED) and Aveiro Health Sciences Program University of Aveiro, 3810-193 Aveiro, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-8255","authenticated-orcid":false,"given":"Philippe","family":"Pierre","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, INSERM, Centre d\u2019Immunologie de Marseille-Luminy (CIML), 13008 Marseille, France."},{"name":"International Associated Laboratory (LIA) CNRS \u201cMistra,\u201d 13008 Marseille, France."},{"name":"Institute for Research in Biomedicine (iBiMED) and Aveiro Health Sciences Program University of Aveiro, 3810-193 Aveiro, Portugal."}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100682"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.09.013"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161293498"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/35047123"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2358"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03547"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001180"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510837103"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2199"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.80"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002708"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104491109"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.5.1011"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg112"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.116"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1201396"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4484"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198326030-00003"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7532"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26109"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809632106"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.06.003"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.11.6592"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.015"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.04116"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070763"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200707166"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135570"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.03.047"},{"key":"e_1_3_2_34_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0031-6997(25)06670-0","article-title":"Structure and function of alpha-adrenoceptors","volume":"43","author":"Ruffolo R. R.","year":"1991","unstructured":"R. R. Ruffolo Jr., A. J. Nichols, J. M. Stadel, J. P. Hieble, Structure and function of alpha-adrenoceptors. Pharmacol. Rev. 43, 475\u2013505 (1991).","journal-title":"Pharmacol. Rev."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9712012"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800771"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080462"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501943"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00291"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-421-0_25"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.6.1057"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1314"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3793"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404271111"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10280"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3755"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.004"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04768"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111202"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00695-1"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302537"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1600"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep08327"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2590"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101669"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.263"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00679"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0463"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-009-0142-9"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3539"},{"key":"e_1_3_2_61_2","first-page":"3651","article-title":"TLR8 deficiency leads to autoimmunity in mice","volume":"120","author":"Demaria O.","year":"2010","unstructured":"O. Demaria, P. P. Pagni, S. Traub, A. de Gassart, N. Branzk, A. J. Murphy, D. M. Valenzuela, G. D. Yancopoulos, R. A. Flavell, L. Alexopoulou, TLR8 deficiency leads to autoimmunity in mice. J. Clin. Invest. 120, 3651\u20133662 (2010).","journal-title":"J. Clin. Invest."}],"container-title":["Science Signaling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1126\/scisignal.aam8104","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/scisignal.aam8104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:10:41Z","timestamp":1751242241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/scisignal.aam8104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":60,"journal-issue":{"issue":"514","published-print":{"date-parts":[[2018,1,23]]}},"alternative-id":["10.1126\/scisignal.aam8104"],"URL":"https:\/\/doi.org\/10.1126\/scisignal.aam8104","relation":{},"ISSN":["1945-0877","1937-9145"],"issn-type":[{"value":"1945-0877","type":"print"},{"value":"1937-9145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]},"article-number":"eaam8104"}}